Citation: Ozgur Karcioglu, et al. Lipid Emulsion Therapy in Poisoning Via Tricyclic Antidepressant Drugs: A Systematic Review. Curr Trends Pharma Clinical Trials 2019, 2(2): 180019. Copyright © 2019 Ozgur Karcioglu, et al. Current Trends in Pharmacology and Clinical Trials ISSN: 2642-0848 Review Article Volume 2; Issue 2 Lipid Emulsion Therapy in Poisoning Via Tricyclic Antidepressant Drugs: A Systematic Review Ozgur Karcioglu 1 *, Ebru Yilmaz 2 , Salim Satar 3 and Selman Yeniocak 4 1 Department of Emergency Medicine, University of Health Sciences, Turkey 2 Department of Emergency Medicine, Nizip Community Hospital, Turkey 3 Department of Emergency Medicine, Adana City Training Hospital, Turkey 4 Department of Emergency Medicine, University of Health Sciences, Turkey *Corresponding authors: Prof. Ozgur Karcioglu, Department of Emergency Medicine, Istanbul Education and Research Hospital, PK 34098, Fatih, Istanbul, Tel: +905055252399; Email: okarcioglu@gmail.com Received Date: May 07, 2019; Published Date: May 21, 2019 Abstract Introduction: Poisoning with drugs are managed with supportive measures in conjunction with lipid resuscitation therapy i.e., intravenous lipid emulsions (ILE). The goal of this technique is to alleviate the clinical manifestations of intoxication via various molecular mechanisms. Poisonings via local anesthetics, cardioactive drugs (calcium-channel blockers and beta blockers), psychoactive drugs [antipsychotics, tricyclic antidepressant drugs (TCAD)] and some others. Methods: This article is a review and critical analysis of the most recent literature to analyse consequences, and intended effects associated with this treatment modality in poisoning with TCAD. Online database searches were performed for randomized controlled trials published before November 2018. The search terms included lipid emulsion therapy, intoxication, poisoning, tricyclic antidepressant drugs, and names of specific compounds in TCADs. Papers were examined for methodological soundness before being included. Studies involving the use of ILE in animal studies on TCAD overdoses were summarized in a table. Results: The initial electronic data search produced 35 potentially eligible trials; among these, 26 were discarded for some reason, and only 9 researches fulfilled the criteria based on inclusion of information set initially. Two other articles were found and enrolled in the review after a search in the references of the articles included. Thus a total of 11 articles were analyzed in the article. Eight studies (72.7%) included in the analysis commented positively on the effectiveness of ILE on TCAD overdoses. Conclusion: Although there are conflicting findings in the literature, ILE may be considered for resuscitation in emergency and intensive care in resuscitation of severe hemodynamic compromise by TCAD. Keywords: Lipid Emulsion Therapy; Lipid Emulsion; Intoxication; Poisoning; Tricyclic antidepressant drugs