_____________________________________________________________________________________________________ *Corresponding author: E-mail: augustineairaodion@yahoo.com; Asian Journal of Biochemistry, Genetics and Molecular Biology 2(2): 1-10, 2019; Article no.AJBGMB.49753 Ameliorative Efficacy of Phytochemical Content of Corchorus olitorius Leaves against Acute Ethanol- induced Oxidative Stress in Wistar Rats Augustine I. Airaodion 1,2* , Emmanuel O. Ogbuagu 3 , Ogbonnaya Ewa 4 , Uloaku Ogbuagu 1 , Olaide O. Awosanya 2 and Olukule A. Adekale 5 1 Department of Biochemistry, Federal University of Technology, Owerri, Imo State, Nigeria. 2 Department of Premedical Science, Educational Advancement Centre, Ibadan, Oyo State, Nigeria. 3 Department of Pharmacology and Therapeutics, Abia State University, Uturu, Nigeria. 4 Department of Medical Biochemistry, Gregory University, Uturu, Abia State, Nigeria. 5 Department of Botany, University of Ibadan, Oyo State, Nigeria. Authors’ contributions This work was carried out in collaboration with all authors. Author AIA conceptualized and designed the study and also wrote the manuscript. Author EOO managed the analyses of the study. Authors OE and UO managed the literature searches. Author OOA wrote the protocol while author OAA performed the statistical analysis. All authors read and approved the final manuscript. Article Information Editor(s): (1) Dr. Mohammed Rachidi, Director of Research, Molecular Genetics of Human-Diseases (MGHD), French Polynesia, University Paris Denis Diderot, Paris, France. Reviewers: (1) Mustafa Sevindik, Biology, Akdeniz University, Turkey (2) Ochieng O. Anthony, Sumait University, Tanzania. (3) Sangeetha A/P Arullappan, Universiti Tunku Abdul Rahman (UTAR), Malaysia. Complete Peer review History: http://www.sdiarticle3.com/review-history/49753 Received 05 April 2019 Accepted 24 June 2019 Published 29 June 2019 ABSTRACT Aim: This study is aimed at investigating the ameliorative efficacy of methanolic extract of Corchorus olitorius leaves against acute ethanol-induced oxidative stress in Wistar rats. Methods: Fresh plants of C. olitorius were harvested from the Institute of Agricultural Research and Training, Ibadan. The leaves were dried and extracted using soxhlet apparatus and methanol as the solvent. The methanol was evaporated in a rotary evaporator at 35°C with a yield of 2.17 g which represents a percentage yield of 8.68%. Twenty adult male Wistar rats with body weight between Original Research Article