28 Page 28-34 © MAT Journals 2019. All Rights Reserved Trends in Pharmaceuticals and Nanotechnology Volume 1 Issue 1 Ionic Liquids : A New Trend in Drug Synthesis Using Green Chemistry Dr. Amit Gosar 1 , Dr. Sayyed Hussain 2 , Tabrez Shaikh 3* , Amit Joglekar 3 1 Chief Scientist, Indoco Remedies Ltd, ARD department, Navimumbai, Maharashtra, India 2 Associate Professor, Sir Sayyed College, Department of Chemistry, Aurangabad, Maharashtra, India 3 Principal Scientist, Indoco Remedies Ltd, ARD department, Navimumbai, Maharashtra, India *Email: tabrezs@indoco.com DOI: http://doi.org/10.5281/zenodo.2597862 Abstract Environmental pollution is majorly caused by the chemical and pharmaceutical industries which have increased multifold time in the last several decades. It is the responsibility of science to design the process which will generate the less hazardous chemicals and much environmentally friendly waste. Ionic liquid finds a source of hope in reducing the organic solvent waste in coming years. These Ionic liquids may replace the organic solvents which are hazardous, toxic and non-environmentally friendly used in the synthesis of chemical compounds. This review article describes the Introduction to Ionic liquids, their types and classification, the advantages of their use in replacement of organic solvent in the synthesis of chemicals compounds and drug substances. Keywords: Ionic liquids, Synthesis, properties, application INTRODUCTION AND DEFINITION Waste is any unwanted material in all the forms that can cause harm by being inhaled, swallowed, and absorbed through the skin or damage the environmental life cycle. The major contribution to environmental waste is organic chemicals which come from various industries. Pharmaceutical industries comprise the largest source of organic pollutants among all the industries while organic solvent waste is major waste which is expelled by these industries. As the world is facing serious environmental challenges, many environmental protection agencies suggested that green chemistry should be used by chemical and pharmaceutical industries in order to reduce toxic, undesired waste, and environmental waste. If the processes can be implemented right, green chemistry can afford to reduce waste product and decrease the resource consumption. Presently the organic waste is the major waste generated in all the manufacturing industries which compromise upto 35 % (Figure-1) of total waste [1-2] Figure 1: Waste pie chart Looking at the Michigan hierarchy waste management chart (Figure-2), avoiding and reducing the amount of chemical waste generated is more preferable and cost-effective when compared to adopting waste management practices such as reducing, recycling, recovering and disposing to the environment. Considering this, the use of Ionic liquid in the manufacturing of pharmaceutical was incorporated in the 1990s in replace of conventional organic solvents. Thus ionic liquids began to be considered as environmentally benign compared to organic solvent [3].