International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 06 Issue: 08 | Aug 2019 www.irjet.net p-ISSN: 2395-0072 © 2019, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 1280 EQUILIBRIUM STUDIES ON TERNARY METAL COMPLEXES OF DRUG ETHAMBUTOL HYDROCHLORIDE WITH NICKEL AND COBALT METAL IONS AND FOUR AMINO ACIDS B K. Magare a and M. B. Ubale b a Shivaji Arts, Commerce and Science College Kannad, Dist. Aurangabad, (M.S.) 431103, India. b Vasantrao Naik Mahavidhyalaya Aurangabad, (M. S.) 431003 India. -----------------------------------------------------------------------***------------------------------------------------------------------------ ABSTRACT: Stability constants of binary and ternary complexes of Co(II) and Ni(II), transition metal ions with ethambutol hydrochloride drug (L) and Serine(R1), Valine(R2), Methionine(R3), Glutamic acid(R4) amino acids have been determined pH metrically at 30 0 C temperature and 0.1 M ionic strength(NaClO4) in aqueous solution. The stability of metal complexes were correlated with structures and discussed in terms of different relative stability parameters. KEYWORDS: stability constants, transition metal, ethambutol hydrochloride, drug, amino acids, and ionic strength. 1. INTRODUCTION The coordination compounds has played a vital role in the field of medicinal and biological sciences [1]. The stability constant of metal complexes with drugs are useful to know the proper dose of drug and their effect with all other components of blood stream as well as to measure the strength of metal ligand bonds [2]. The complexes of drugs are more potent than drug [3]. The studies of complex equilibria of metal ions with drugs help to elucidate the mechanism of action of drugs [4]. The role of transition metal ions and their complexes are involved in metabolism, transportation, and catalytic processes in the systems [5-9]. Amino acids are the basic structural unit of proteins and played paramount role in the cell structure and functions. They are essential for growth and metabolism processes. The ethambutol hydrochloride drug (L) [Chemical name of drug is 2,2’ethylenediamine-di-butanol hydrochloride] is an antitubercular drug that inhibits the transfer of mycolic acids into cell wall of tubercle bacillus [10] and is effectively used against actively growing micro-organism of Genus mycobacterium and structure is shown in Figure 1. C N H OH H N OH CH 3 .HCl. H 3 Figure 1: Structure of ethambutol hydrochloride drug (L). The literature survey reveals that very limited work of ternary complexes of transition metal ions with drugs and amino acids have been reported [11-14].Hence the present paper deals with the systematic study of stability constants of ternary complexes of Co(II), Ni(II), metal ions with ethambutol hydrochloride drug(L) and a series of four amino acids (R). 2. EXPERIMENTAL 2.1 Materials and solutions All the chemical reagents used in the present investigation were A. R. grade. The solutions of reagents were prepared in carbonate free doubled distilled water having 6.80-6.90 pH. The NaOH solution was standardized with oxalic acid and kept in Pyrex vessel. The 1.0 M sodium perchlorate (NaClO4) solutions were prepared to maintain the 0.1 M ionic strength of the solutions by taking requisite amount of sodium per chlorate. The metal nitrates were used to prepare the metal solutions and were standardized by usual procedure [15].