ORIENTAL JOURNAL OF CHEMISTRY www.orientjchem.org An International Open Free Access, Peer Reviewed Research Journal ISSN: 0970-020 X CODEN: OJCHEG 2016, Vol. 32, No. (5): Pg. 2585-2598 An Electrochemical Study of POPC Phospholipid Bilayers in a Cell Membrane A. ELSAGH, K. ZARE and M. MONAJJEMI* Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran. *Corresponding author E-mail: m_monajjemi@srbiau.ac.ir http://dx.doi.org/10.13005/ojc/320530 (Received: June 03, 2016; Accepted: August 17, 2016) ABSTRACT In this study, we have shown the model of a microscale dielectric membrane capacitor including POPC structures. We have shown that Quantum effect has appeared in a small free space of the membrane thickness due to number of phospholipids layers. In addition, we have speciûcally investigated the quantum and coulomb blocked effects of diûerent thickness. Furthermore, the electron density profile models, electron localization function (ELF) and local information entropy have been applied as a formal way to studies the interaction of protein with lipid bilayers in cell membrane. Keywords: Variable capacitor, Lipid bilayers, POPC, Cell membrane. INTRODUCTION 1-palmitoyl-2-oleoylsn-glycero-3- phosphocholine bilayers (POPC) has important rule in the electrochemical properties of a cell membrane in the fluid phase. The composition of a cell membrane directly affects cell membrane functions include membrane permeability, cell signaling, and cell capacitance 1-2 . Volke and Pampel were the first to report that cross peaks between the lipid 1-palmitoyl-2- leolyl-sn-glycero-3-phosphocholine (POPC) and water at a concentration of nine water molecules per POPC have negative intensity, compared to positive intensity for all lipid–lipid cross peaks 3 . The laboratories of Stark confirmed that cross peaks between water and lipid head groups have negative intensity, but the cross peak to the methylene resonance of hydrocarbon chains was weak and positive 4 . The lipid portion of the membrane serves various barrier functions, preventing most molecules and ions from passing in or out. The membrane covered on both sides by collections of charged dissolved minerals, which serve the same function as a conducting metal plate.