Available online at www.ijpsdr.com 454 International Journal of Pharmaceutical Sciences and Drug Research 2018; 10(6): 454-459 Research Article ISSN: 0975-248X CODEN (USA): IJPSPP Antiulcer Activity of Methanolic Extract of Roots of Beta vulgaris, Chenopodiaceae Manoj Jagannath Jagtap 1 , Amol Bhalchandra Deore 2* 1 Department of Pharmacology, Mahatma Gandhi Vidyamandir’s Institute of Pharmacy, Malegaon-423203, Nashik, Maharashtra, India 2 Department of Pharmacology, Maratha Vidya Prasarak Samaj’s Institute of Pharmaceutical Sciences, Adgaon-422003, Nashik, Maharashtra, India Copyright © 2018 Manoj Jagannath Jagtap et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which allows others to remix, tweak, and build upon the work non- commercially, as long as the author is credited and the new creations are licensed under the identical terms. ABSTRACT Beta vulgaris (chenopodiacea) is a medicinal plant reported for its variety of ethnic medicinal uses. Beta vulgaris showed antioxidant, anticancer, hepatoprotective, nephroprotective, wound healing, and anti-inflammatory activities. Hence we have planned to screen antiulcer activity of root of the plant with the methanolic extract. Root powders successively extracted with methyl alcohol and were subjected for phytochemical screening to identify different phytoconstituents. The methanolic extracts of roots of Beta vulgaris were investigated for ulcer protective activity against pyloric-ligation, ethanol induced gastric lesion and cold restraint stress induced ulcers. Preliminary phytochemical screening revealed the presence of flavonoids, saponins, sterols, and alkaloids. The extract was tested for their lethal effect up to the dose level of 2000 mg/kg. None of them have produced abnormal behavior or mortality in rats. Further methanolic extract of 200 and 400 mg/kg/p.o significantly (p˂0.01) reduced the ulcer score, ulcer number, ulcer index, free acidity and total acidity in pyloric- ligation, ethanol induced gastric lesion and cold restraint stress induced ulcer models in rats. The present study revealed that the root extract of Beta vulgaris has antiulcer activity. Keywords: Pyloric-ligation, gastric lesion, ulceration, wound healing. DOI: 10.25004/IJPSDR.2018.100605 Int. J. Pharm. Sci. Drug Res. 2018; 10(6): 454-459 *Corresponding author: Mr. Amol Bhalchandra Deore Address: Department of Pharmacology, Maratha Vidya Prasarak Samaj’s Institute of Pharmaceutical Sciences, Adgaon-422003, Nashik, Maharashtra, India Tel.: +91-9011176272 E-mail : amoldeore22@gmail.com Relevant conflicts of interest/financial disclosures: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Received: 14 August, 2018; Revised: 06 October, 2018; Accepted: 12 October, 2018; Published: 20 November, 2018 INTRODUCTION Peptic ulcer (encompassing gastric ulcer and duodenal ulcer) is a major health hazard both in terms of morbidity and mortality. A peptic ulcer results from an imbalance between some endogenous aggressive factors [hydrochloric acid, pepsin, refluxed bile, leukotrienes, reactive oxygen species (ROS)] and cytoprotective factors, which include the function of the mucus-bicarbonate barrier, surface active phospholipids, prostaglandins (PGs), mucosal blood