202 The Journal of Qazvin University of Medical Sciences (JQUMS) August, September 2019. Vol 23. Num 3 * Corresponding Author: Abbas Saremi Address: Department of Exercise Physiology, School of Sport Sciences, Arak University, Arak, Iran. Tel: +98 (916) 3622668 E-Mail: a-saremi@araku.ac.ir Research Paper The Impact of a Resistance Training Period on Lipasin Plasma Level and Lipid and Metabolic Profle in Obese Rats 1. Department of Exercise Physiology, School of Sport Sciences, Arak University, Arak, Iran. 2. Department of Anatomy, School of Medical Sciences, Arak University of Medical Sciences, Arak, Iran. 3. Department of Physiology, School of Medical Sciences, Arak University of Medical Sciences, Arak, Iran. * Abbas Saremi 1 , Mohammad Bayat 2 , Mahdi Sadegh 3 , Jamal Amiri 2 Background Lipasin is a liver-derived secretory protein; i.e. associated with type 2 diabetes mellitus, obe- sity, and metabolic syndrome. Objectve The current research assessed the efect of resistance training on atherogenic and metabolic status and lipasin levels in obese rats. Methods In this experimental study, 20 obese rats (8 weeks old, Mean±SD weight: 361±32 g) and 10 normal-weight rats (8 weeks old, Mean±SD weight: 248±13 g) randomly divided into three groups: obese control, obese trained, and control. The obese trained group received an 8-week exercise pro- gram for 3 days/week on a specifc ladder with a carrying load of 30% of body weight, atached to their tails. The weight of the load was gradually increased during the training sessions, reaching 200% of the body weight of rats in the fnal week. There were three sets of 5 repettons with a 3-min rest between each set of exercise sessions and 1 minute between repettons. Forty-eight hours afer the last training session, the blood samples were obtained and analyzed for metabolic status. The collected data were analyzed using analysis of variance (ANOVA), and statstcal signifcance was set at P<0.05. Findings Lipasin levels were higher in obese rats, than the controls (P=0.02). Atherogenic and meta- bolic status (TG, TC, LDL, glucose, insulin resistance) were improved in the exercise group, com- pared to the control group (P=0.05). Plasma lipasin levels were signifcantly decreased in the obese exercise group (P=0.05). Conclusion This study indicated that resistance training may be efectve in improving metabolic status by decreasing lipasin plasma levels. A B S T R A C T Keywords: Lipasin, Obesity, Resistance training, Metabolic status Received: 28 Feb 2019 Accepted: 11 Jun 2019 Available Online: 01 Aug 2019 Citaton Saremi A, Bayat M, Sadegh M, Amri J. The Impact of a Resistance Training Period on Lipasin Plasma Level and Lipid and Metabolic Profle in Obese Rats. The Journal of Qazvin University of Medical Sciences. 2019; 23(3):202-213. htps://doi.org/10.32598/ JQUMS.23.3.202 : htps://doi.org/10.32598/JQUMS.23.3.202 Use your device to scan and read the artcle online Extended Absract 1. Introduction besity is one of the mos common diseases that its incidence rises progressively world- wide. This problem is associated with an increased risk of catching cardiovascular diseases and type II diabetes [1]. The liver plays a key role in lipid, glucose, and choleserol metabolism. Besides, it produces and releases secretory proteins called hepatokines [2]. Lipases, also known as angiopoietin-like protein, is a newly identifed circulating protein predominantly pro- duced in the liver and adipose tissue [3-6]. Clinical sudies have clarifed some relations between the circulating levels of human lipase with obesity and diabetes. The circulating O