International Journal of Chemistry Studies 1 International Journal of Chemistry Studies ISSN: 2581-348X Impact Factor: RJIF 5.44 www.chemistryjournal.in Volume 2; Issue 3; May 2018; Page No. 25-29 Antihyperlipidemic effect of some medicinal plants used in Bangladeshi traditional medicine: A review Md. Khairul Alam 1 , Mohammad Abu Bin Nyeem 2 , AKM Mamun Ur Rashid 3 , Md. Abdul Mannan 4 , Md. Monir Ahammed 5 1, 2, 4 Department of Unani Medicine, Hamdard University Bangladesh, Bangladesh 3 Department of Public Health, American International University-Bangladesh, Bangladesh 5 Department of Ayurvedic Medicine, Hamdard University Bangladesh, Bangladesh Abstract Hyperlipidemia is major risk factor for the atherosclerosis. Other complications are coronary heart disease, ischemic cerebro vascular disease, hypertension, obesity and diabetes mellitus. Although many efficacious lipid-lowering synthetic drugs exist, none is effective for all lipoprotein disorders, and all such agents are associated with some adverse effects. Now day’s synthetic drugs have been associated with number of side effects but herbal medicines have lipid lowering activities without any side effects. Some traditionally herbs like Allium sativum, Terminalia arjuna, Cassia angustifolia, Cinnamomum tamala, Gymnema sylvestre, Hibiscus cannabinus, Mimosa pudica, Moringa oleifera, Sida cordifolia, Hemidesmus indicu, Terminalia pallid, etc. are used as antihyperlipidemic drug as per Unani and Ayurvedic literature. The article is undertaken to investigate the herbal plants for Antihyperlipidemic activity and models use in this investigation. This review is given on the antihyperlipidemic activity of the most familiar medicinal plants of medicine. This matter may be helpful for the researchers, academician and preclinical about the potential herbs having antihyperlipidemic activity. Keywords: hypolipidemic agents, hypolipidemic medicinal plants Introduction Hyperlipidemia is define in a simple way by increase serum total count (TC), triglycerides (TG), VLDL, LDL and IDL which are responsible for various complications like: heart attack, premature coronary artery disease, stroke, atherosclerosis, myocardial infarction and pancreatitis [1] . Cardiovascular diseases contributed to approximately a third of entire global deaths, It is expected that it will become the leading cause of death and disability worldwide [2] . Hyperlipidemia is a major cause of atherosclerosis and atherosclerosis - Associated conditions such as coronary heart diseases (CHD), ischemic cerebrovascular disease, and peripheral vascular diseases [3] . Atherosclerosis referred to as a “silent killer” is one of the leading causes of death in the developed countries and is on the rise in developing countries like India [4]. The American Heart Association has identified the primary risk factor associated with atherosclerosis as elevated levels of cholesterol and triglycerides in the blood. Therefore, therapists consider the treatment of hyperlipidemia to be one of the major approaches toward decelerating the atherogenic process [5] . Allopathic hypolipidemic drugs are available at large in the market, but the side effects and contraindications of these drugs [6] . Medicinal plants play a key role in the human health care. About 80% of the world population relies on the use of traditional medicine which is predominantly based on plant materials [7] . Plants and plant derived product are part of health care since time immemorial. In treatment of various ailments including cardiovascular diseases, herbal drugs play an important role. Effective therapeutic agents with a low incidence of side-effects are in need by physicians and patients and plants potentially constitute such a group. A variety of plants have been studied which support cardiovascular functions and are used to treat diseases of the heart, but still there is a need to explore more cardio protective plants. Studies on ethno-medicinal plants are of great advantage for producing herbal drugs. The local people possess good knowledge of herbal medicines regarding its preparation and use. Hence it is important to study and record their use of medicinal plants. Allium sativum The present study is designed to evaluate the effect of garlic extract on lipid profiles in Triton X-100 induced hyperlipidemia in male wistar rats. Three fractional extracts of Allium sativum (AS) (AS1, AS2 and AS3) were obtained by column chromatography from methanolic extract of garlic. All three garlic extract significantly increased (p < 0.0001) plasma HDL-Cholesterol and decreased plasma TC, LDL-Cholesterol and TG levels as compared with hyperlipidemic control. Among three fractions, AS3 has more significantly reduced the plasma lipid levels than others AS1and AS2 [8] . Garlic has been used as a dietary agent through-out the world. Different culture used different varieties of garlic depending upon their ecological productivity. In India Allium sativum species of garlic is very commonly used, while another species of garlic named Allium tuberosum is used in South- east Asia, China and North-east part of India. Both the species are important constituent of customary diet in Indian and Chinese food. The main aim of this study is to compare the potency of these two species for their antihyperlipidemic effect and curative potential against atherosclerosis. Forty-