Arch Clin Biomed Res 2019; 3 (6): 361-373 DOI: 10.26502/acbr.50170080 Archives of Clinical and Biomedical Research Vol. 3 No. 6 – December 2019. [ISSN 2572-9292]. 361 Review Article Pathogenesis and the emerging Therapy of Vitiligo Abdur Rahim Zar 1 , Abdul Malik 1 , Asif Mahmood 2, Qais Ahmad Naseer 2 , Li Yumei 3* 1 Department of Dermatology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China 2 Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China 3 The affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China *Corresponding author: Li Yumei, Affiliated Hospital of Jiangsu University Zhenjiang, Jiangsu 212001, China. E-mail: l.yumei@aliyun.com Received: 16 October 2019; Accepted: 22 October 2019; Published: 08 November 2019 Citation: Abdur Rahim Zar, Abdul Malik, Asif Mahmood, Qais Ahmad Naseer, Li Yumei. Pathogenesis and the emerging Therapy of Vitiligo. Archives of Clinical and Biomedical Research 3 (2019): 361-373. Abstract Vitiligo is a common and a disfiguring autoimmune disease, which has a negative impact on patients' self- esteem and quality of life. Pathogenesis of Vitiligo involves the interaction between defects of natural and extrinsic melanocytes, immune innate to swelling and destruction of T-cell-mediated melanocyte. Vitiligo affects about 1% of the general population. The risk of the disease was 6% for siblings and 23% for identical twins treatment is not only intended to stop the disease, but also to support repigmentation through the regeneration, proliferation and migration of melanocytes. Treatment strategies for dealing with all aspects of pathogenesis and pigmentation can be very effective, and this strategy may require a combination. Current treatments generally do not imply objective autoimmunity, and emerging treatments may use more specific methods based on a deep understanding of the pathogenesis of the disease, which can provide a good safety profile with a higher effectiveness. However, as with most medical treatments, careful patient selection and monitoring should enable us to normalize the pathogenic response of vitiligo in order to achieve the internal balance of healthy individuals. Keywords: Vitiligo; Disease; Pathogenesis; Melanocytes Introduction Vitiligo is a common and disfiguring autoimmune disease, which has a negative impact on patients' self- esteem and quality of life [1, 2]. The current treatment