________________________________________ * Author for correspondence; E-mail: adnanimchem@yahoo.com Int. J. Chem. Sc.: 11(1), 2013, 1-11 ISSN 0972-768X www.sadgurupublications.com COPPER (I) CATALYZED SYNTHESIS AND BIOLOGICAL EVALUATION OF TETRAKIS-1,2,3-TRIAZOLES BASED ON D-IDITOL ADNAN IBRAHIM MOHAMMED * , RASHA SAAD JWAD a and NABEELA A. Al-RADHA b Department of Chemistry, College of Science, Kerbala University, KERBALA, IRAQ a Department of Chemistry, College of Science, Al-Nahrain University, BAGHDAD, IRAQ b Department of Chemistry, College of Education, Al-Qadisiya University, AL-QADISIYA, IRAQ ABSTRACT This work describes the synthesis of D-iditol based tetrakis-1,2,3-triazoles. In the first approach, in which the heterocyclic portions were built from the click 1,3-dipolar cycloaddition of n-octyl azide, n-nonyl azide and n-decyl azide, respectively with propagyl alcohol. Alkynyl triazoles 4 a-c were readily prepared in very good yields under biphasic conditions from the corresponding triazolyl alcohols 3 a-c and propargyl bromide in the presence of NaOH pellets in DMF. 3,4-Diazido-3,4-dideoxy1,2 : 5,6-di-O- isopropylidene-D-iditol 7 was prepared in three subsequent steps from D-mannitol. The reaction of 7 with propargyl ethers 4 a-c under Cu (I)-catalyzed Huisgen-Meldal 1,3-dipolar cycloaddition conditions gave the desired tetrakis-1,2,3-triazole derivatives 8 a-c in very good yields. Removal of the acetal groups of 8 a-c using Amberlite IR 120 H + in EtOH afforded the deprotected tetrakis triazoles 9 a-c in excellent yields. The synthesized compounds have characterized by TLC, FTIR, CHN and most of them by NMR. The biological activities of the synthesized compounds 8 and 9 were measured in vitro against different types of bacteria, some of the prepared compounds showed activity against the microorganism. Key words: Tetrakis-1,2,3-triazoles, D-iditol, Click chemistry, 1,3-dipolar cycloaddition, Biological activity. INTRODUCTION 1,2,3-Triazoles verified to be one of the important heterocyclic compounds because of their wide range of biological uses 1,2 . These heterocycles have displayed various biological activities such as anti-HIV activity 3 , antitubercular agents 4 , antifungal 5 , antibacterial 6 , antibiotic 7 , and anticancer 8 . Introduction of carbohydrate moiety to the triazole core increasing the hydrophilicity of the whole molecule, which helps in the