IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 18, Issue 5 Ser. 12 (May. 2019), PP 31-35 www.iosrjournals.org DOI: 10.9790/0853-1805123135 www.iosrjournals.org 31 | Page Study of Blood Group (ABO and RH) Association and Secretor Status of ABH Substances in Patients with Systemic Lupus Erythematosus Dr. Tashi Paleng 1 , Dr. A. Barindra Sharma 2 , Dr.Santa Naorem 3 , Dr. Laikangbam Dayalaxmi 4 , Dr. Eric Hilton Wanniang 5 , Dr. Eswara Moorthy G 6 1 Postgraduate trainee, 2 Professor & Head, 3 Professor, 4 Senoir Resident, 5 Postgraduate trainee, 6 Postgraduate trainee 1,2,4,5,6 Department of Transfusion Medicine, 3 Department of Medicine, Regional Institute of Medical Sciences, Imphal-795004, Manipur, India Corresponding Author: Dr. Tashi Paleng Abstract: Individuals who secrete their blood group antigens in the body fluids are called secretors and individuals who do not secrete are called non-secretors. Non-secretors of blood group antigens have been found to be associated with many infectious and autoimmune diseases by many previous studies. The aims of our study were to find out any association between ABO blood group, RhD blood group and secretor status of ABH substances with the patients of Systemic Lupus Erythematosus. This Case Control study was carried out in the Department of Transfusion Medicine in collaboration with the Department of Medicine, Regional Institute of Medical Sciences, Imphal Manipur from September 2016 to August 2018. 75 confirmed SLE patients attending Rheumatology OPD, Department of Medicine and 75 healthy sex matched voluntary blood donors attending blood bank, Department of Tranfusion Medicine have been enrolled in the study. Their blood were typed for ABO and RhD groups using conventional tube technique and saliva were tested for secretor and non-secretor status using heamagglutination inhibition test. In SLE group, there were 45.3% with A blood group followed by O (36%), B (14.7%) and AB (4%) and in non-SLE group 36% were with A blood group followed by O (29.3%), B (22.7%) and AB (12%). There were no significant association between SLE status and ABO blood groups ( p= 0.133). Majority of participant in SLE were A RhD +ve (45.3%) followed by O RhD +ve (34.7%), B RhD +ve (14.7%), AB RhD +ve (4%) and O RhD –ve (1.3%) and in non-SLE group 36% were A RhD +ve followed by O RhD +ve (28%), B RhD +ve (22.7%), AB RhD +ve (9.3%) and O RhD –ve (1.3%). A non- significant p value (p=0.285) infers that there is no significant association between RhD blood group and SLE.Among individual with SLE, 40% were non-secretors and in non-SLE only 14.7% were non-secretors. Therefore the odds of non-secretors develop SLE is 3.86 times when compared to non-SLE group. Therefore, it appears that non-secretor individuals are more prone to develop SLE. --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 08-05-2019 Date of acceptance: 24-05-2019 --------------------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Systemic lupus erythematosus (SLE) is a chronic, relapsing, often febrile multisystemic autoimmune disorder affecting principally the skin, joints, kidneys and serosal membranes and lacking a single unifying pathognomic marker. The prevalence rate in India is approximately 1 in 2000 of the population. The term lupus means wolf in Latin and originally denoted wolf bite like facial lesions. Cazenave in France coined the term „lupus erythematosus‟ in 1833.1 Systemic lupus erythematosus is an autoimmune disease in which organs and cells undergo damage initially mediated by tissue-binding autoantibodies and immune complexes. In most patients, autoantibodies are present for a few years before the first clinical symtoms appears; clinical manifestation are heterogeneous. Ninety percent of patients at diagnosis are women of childbearing years; people of all genders, ages, and ethnic groups are susceptible. The diagnosis of SLE is based on characteristic clinical features and autoantibodies. Any combination of ≥4 of 11 diagnostic criteria well documented at any time during an individual‟s history makes it likely that the patient has SLE ( specificity and sensitivity are 95% and 75% respectively ). In many patients criteria accrue over time. Antinuclear antibodies (ANA) are positive in >98% of patients during the course of disease, repeated negative tests suggest that the diagnosis is not SLE unless other autoantibodies are present. High titres IgG antibodies to double-stranded DNA and antibodies to the Sm antigen are both specific for SLE and therefore favour the diagnosis in the presence of compatible clinical manifestation.2 Individuals can be classified as secretors and non-secretors according to their ability to secrete