IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 18, Issue 5 Ser. 12 (May. 2019), PP 83-89 www.iosrjournals.org DOI: 10.9790/0853-1805128389 www.iosrjournals.org 83 | Page Analysis of CRP Level in Serum of Preeclamptic Women with Periodontal Disease N.Chitra 1 , A. Santhadevy 2 , K.R.Premlal 3 , P.Pallavee 4 , M.Sathish Babu 5 , R.Suganya 6 1. Dr. N. Chitra ,Post Graduate, Department of Oral Pathology and Microbiology, Indira Gandhi Institute of Dental sciences, Sri Balaji Vidyapeeth Deemed to be university, Puducherry. 2. Dr. A. Santha Devy MDS, Professor and Head , Department of Oral Pathology and Microbiology, Indira Gandhi Institute of Dental sciences, Sri Balaji Vidyapeeth Deemed to be university, Puducherry. 3. Dr. K. R. Premal, Reader, MDS, Department of Oral Pathology and Microbiology, Indira Gandhi Institute of dental sciences, Sri Balaji Vidyapeeth Deemed to be university, Puducherry. 4. P.Pallavee, Professor, MD, Department of Obstetrics and Gynaecology, Mahatma Gandhi Medical college and Research Institute, Sri Balaji Vidyapeeth Deemed to be university, Puducherry. 5. Dr. M. Sathish Babu MD, Associate Professor, Department of Biochemistry, Jipmer, Karaikal. 6. Dr. R.Suganya MDS, Reader, Department of Oral Pathology and Microbiology, Indira Gandhi Institute of dental sciences, Sri Balaji Vidyapeeth Deemed to be university, Puducherry Corresponding author: Dr.A. Santhadevy Abstract: Objective: Preeclampsia is the major cause for feto-maternal complication affecting 5-10% of all pregnancy. Periodontitis has also been associated to be one among the causative factors for it. As these have adverse effects upon pregnant women, the present study was intended with an objective to determine the importance of an inflammatory marker C-Reactive protein level in pregnant women with periodontal disease and to correlate with the severity of periodontitis in preeclamptic pregnant women and also to determine the salivary pH , flow rate and specific gravity . Methods: The study included 60 preeclamptic pregnant women from whom 2 ml of venous blood was taken from the sample already collected for routine investigation. Informed consent were obtained from research participants. Estimation of CRP level was done from the collected samples using latex agglutination slide test. Simultaneously, periodontal examination was also done for these patients. Results: Among the 60 preeclamptic patients included in the survey, 53(88.3%) were noticed with mild periodontal disease and 7(11.7%) were noticed with moderate periodontal disease. The mean CRP level for patients with mild and moderate periodontal status was 1.155 ± 1.8 and 9.26 ± 9.4 respectively and the difference was statistically significant (p= 0.001). Conclusion: This showed that mean CRP level among patients with moderate periodontal diseases was higher than that of mild periodontal disease which indicates that CRP can be used as a marker of inflammation. Key words: C-reactive protein, inflammation, inflammatory markers, periodontitis, preeclampsia. --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 09-05-2019 Date of acceptance: 25-05-2019 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Infections and inflammation is gradually increasing globally and has become a pandemic burden. Inflammation, especially, is known to play a vital role in the pathogenesis of various systemic and oral diseases in individuals and is associated and influenced with each other. 1 Among these, oral infections have been implicated and associated as causative agents in variety of systemic illness that includes atherosclerotic cardiovascular diseases and cerebrovascular ischemia. There are numerous oral infections such as dental caries, periapical infections, periodontal infections etc. among which, the microorganisms in periodontal diseases expose the host to microbial challenge, bacterial antigens and virulence factors leading to persistent inflammation that influence certain systemic diseases. Studies have also shown that relationship exists between periodontitis and pregnant women, who, with poor oral health might be at higher risk of developing pregnancy complications such as preterm delivery and