IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 18, Issue 6 Ser. 12 (June. 2019), PP 42-44 www.iosrjournals.org DOI: 10.9790/0853-1806124244 www.iosrjournals.org 42 | Page A Comparative Study of Serum Lipid Profile in Preeclamptic With Normotensive Pregnant Women Dr.Gulab Kanwar 1 , Dr.Shipra Jain 2 , Dr.Sonia Jain 3 , Dr.Pravin Kothari 4 , Dr.Manish Jain 5 1- Senior Professor &Head OfDepartment, GovtMedical College, Kota Rajasthan .India. 2- Senior Demonstrator Department Of Biochemistry GovtMedical College, Kota Rajasthan. India. 3- Lady Medical Officer In Hindustan Zinc Ltd, Chittorgarh ,India. 4- Medical Officer, Satellite Hospital ,Rampura,, Kota, India . 5- Consultant surgeon, kota . India Abstract: Background: Preeclampsia is becoming very common complicationamong pregnant women and higher cause of morbidity and mortality.Maternal serum lipids are significantly elevated during pregnancy.Women who develop preeclampsia experience even more lipid changes as compare to normal pregnant women. Aims and Objective: To compare serum levels of lipid profile (STG,TC, HDL-C,VLDL, LDL) in preeclamptic pregnant women compared with normotensive pregnancy. Material and method: The study was conducted inGeetanjali MedicalCollegeand hospital, Udaipur, Rajasthan .The duration of this study was from January 2014 to December 2014. The total 100 pregnant women were studied in which 50 were preeclamptic and 50 were normotensive pregnant (primigravidae) women of age group between 18-35 yrs. The serum was analyzed for lipid profile by colorimetric method on Erba CHEM 5 Plus v2 in department of biochemistry GMCH Udaipur, Rajasthan. Statistical analysis was done on Microsoft excel. Continuous parameters were expressed as mean±SD. The results were analysedbystudent’s t- test. P value<0.05was consideredas statistically significant. Conclusion: By this study we conclude that serum concentration of lipid parameters( TG , VLDL, LDL, TC) are higher and S-HDL is lower in preeclamptic cases as compare to normotensive pregnant control. Keywords: Dyslipidemia, Endothelium, Hypertension, , Oxidative Stress, Preeclampsia. --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 06-06-2019 Date of acceptance: 21-06-2019 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Preeclampsia is one of the leading causes of maternal mortality and morbidity and preterm delivery worldwide. 1 . The incidence of preeclampsia in developing countries is around 4-18%and in India is 5-15%. Preeclampsia is a pregnancy specific disorder, characterized by pregnancy induced hypertension(BP≥140/90mm Hg) on two occasion, atleast 6 hours apart and proteinuria of ≥ 300 mg/24 hours or ≥ 1 +dipstick after 20 weeks of gestation in previous normotensive women. It occurs in about 2-8% of pregnancies 2 . Women who develop preeclampsia experience even more lipid changes as compare to normal pregnant women. Preeclampsia-dyslipidemic pattern of increased triglycerides, cholesterol, low density lipoprotein cholesterol (LDL-C), and decreased high density lipoprotein cholesterol (HDL-C) concentration 3- 6 .Hypercholesterolemia leads to excessive lipid peroxidation and coexistent diminution in antioxidant activity leads to an imbalance between peroxidases and antioxidants, resulting in oxidative stress. Oxidative stress and elevated AI may contribute to atherogenicity in pre-eclampsia 7 II. Aims And Objectives To compare serum levels of lipid profile (STG,TC,HDL-C,VLDL, LDL) in preeclamptic pregnant women compared with normotensive pregnancy. III. Material And Method Study population:This study was a case control and hospital based which was carried out in department of obstetrics and gynaecology, and department of biochemistry GMCH , Udaipur from January 2014 – December 2014.Among 100 pregnant women 50women were preeclamptic (cases) and 50 women were normotensive pregnant (control).