_____________________________________________________________________________________________________ *Corresponding author: E-mail: talhajawaid78@gmail.com; Journal of Pharmaceutical Research International 31(6): 1-9, 2019; Article no.JPRI.53655 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Evaluation of Antidepressant and Anxiolytic Activity of Solanum melongena L. Fruits Aqueous Extract via Monoaminergic and GABAergic Pathway Talha Jawaid 1* , Nidhi Tiwari 2 , Mehnaz Kamal 3 , Osama A. Alkhamees 1 , Ali M. Alaseem 1 , Waleed M. Al Shagha 1 and Saud M. Alsanad 1 1 Department of Pharmacology, College of Medicine, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), P.O. Box 11623, Riyadh 11544, Saudi Arabia. 2 Hygia Institute of Pharmaceutical Education and Research, Lucknow, India. 3 Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box No. 173, Al Kharj 11942, Saudi Arabia. Authors’ contributions This work was carried out in collaboration among all authors. Authors TJ, NT and MK participated in the conception of the study and the research question. Authors NT and TJ performs review work and experimental designing. Authors OAA, AMA, WMAS and SMA defined and discussed the outcomes of interest. Authors TJ and NT performed the extraction and preliminary drafting of the results. Authors OAA, AMA and MK carried out the cost estimates. Authors TJ, NT, MK, OAA, AMA, WMAS and SMA reviewed the results and delineated. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2019/v31i630371 Editor(s): (1) R. Deveswaran, M. Pharm, Ph. D. Associate Professor and Head-Drug Design and Development Centre, Faculty of Pharmacy, M. S. Ramaiah University of Applied Sciences, Bangalore - 560054, India. Reviewers: (1) Camilo Torres-Serna, Universidad Santiago de Cali, Colombia. (2) Ayobolla Abolape Iyanda, Nigeria. (3) Euclides Mauricio Trindade Filho, State University of Health Sciences of Alagoas, Brazil. (4) Jadwiga Sołoducho, Wrocław University of Science and Technology, Poland. Complete Peer review History: http://www.sdiarticle4.com/review-history/53655 Received 28 October 2019 Accepted 01 January 2020 Published 06 January 2020 ABSTRACT The current study proposed the in vivo antidepressant and anxiolytic activities of the aqueous extract from Solanum melongena fruits (AESM) in mice. The mice were administered with AESM 100 and 200 mg/kg, p.o. for anxiolytic (elevated plus maze test (EPMT) and locomotor action), and antidepressant (forced swimming test (FST) and tail suspension test (TST) activities. The possible Original Research Article