IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 18, Issue 11 Ser.2 (November. 2019), PP 27-33 www.iosrjournals.org DOI: 10.9790/0853-1811022733 www.iosrjournals.org 27 | Page Serological Surveyand Risk Factors Associated with Oncogenic Human Papilloma Virus among Women of Reproductive Age in Funtua Zone Katsina State, Nigeria 1 Abdulkadir B. 1 Hayatudeen M.R, 1 Ahmad M, 2 Aminu M, 3 Shuaibu M,and 4 Oyero, S.K 1 Department of Microbiology, Faculty of Science, Umar Musa Yar’adua University, Katsina. 2 Department of Microbiology, Faculty of Science, Ahmadu Bello University Zaria-Nigeria 3 Department of Histopathology, Federal Medical Center Katsina, Katsina Sate Nigeria 4 Department of Histopathology, Jos University Teaching Hospital, Jos Plateau State-Nigeria Corresponding Author: Abdulkadir B Abstract: Papillomaviruses are ubiquitous and are members of a family Papillomaviridae of DNA viruses that infect humans and animals. Human papillomaviruses (HPVs) are small non-enveloped viruses that contain a double-stranded, closed circular DNA genome. Human papillomaviruses cause anogenital warts and are associated with anogenital malignancy including cervical, vaginal, vulvar, penile, and anal carcinoma.This study was carried out to determine the prevalence of HPV IgM among women of reproductive age and associated risk and demographic factors in Funtua zone, Katsina state. A cross-sectional serological survey enrolling 60 women of reproductive age attending ANC of General Hospital Funtua. Serum samples were obtained from randomly selected subjects. Samples were tested IgM HPV specific commercial enzyme-linked immunosorbent assay (ELISA) kit. The overall prevalence of was (36.6%) recorded.There was no statistical significant association between women of reproductive age with sociodemorgraphic and risk factors analysed in this studies (P < 0.05). Women of reproductive age attending ANCshould be screened for HPV infection and further studies with larger sample size is recommended. Since infection with HPV is life-long and has no known cure, primary prevention remains the mainstay of its control. Keywords: HPV, DNA, prevalence, IgM, ELISA. --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 24-10-2019 Date of Acceptance: 09-11-2019 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction An HPV infection is caused by human papillomavirus, a DNA virus from the papillomavirus family, of which over 170 types are known (Bzhalava et al., 2013). More than 40 types are transmitted through sexual contact and infect the anus and genitals (CDC, 2015). Risk factors for persistent HPV infections include early age of first sexual intercourse, multiple partners, smoking, and poor immune function (WHO, 2010). HPV is typically spread by sustained direct skin-to-skin contact with vaginal and anal sex being the most common methods. Occasionally, it can spread from a mother to her baby during pregnancy (CDC, 2015). It does not spread via common items like toilet seats (CDC, 2015). People can become infected with more than one type of HPV (CDC, 2015). HPV is the most common sexually transmitted infection globally (Milner and Danny, 2015). Most people are infected at some point in their lives (CDC, 2015). In 2012, about 528,000 new cases and 266,000 deaths occurred from cervical cancer worldwide (WHO, 2014). Around 85% of these occurred in the developing world (WHO, 2010). In the United States, about 27,000 cases of cancer due to HPV occur each year. About 1% of sexually active adults have genital warts (CDC, 2015). While cases of warts have been described since the time of ancient Greece, their viral nature was not discovered until 1907 (Tyringet et al., 2016). Human papillomaviruses (HPVs) are a group of more than 200 related viruses. More than 40 HPV types can be easily spread through direct sexual contact, from the skin and mucous membranes of infected people to the skin and mucous membranes of their partners. They can be spread by vaginal, anal, and oral sex other HPV types are responsible for non-genital warts, which are not sexually transmitted (ACS, 2014). Sexually transmitted HPV types fall into two categories: Low-risk HPVs, which do not cause cancer but can, cause skin warts (technically known as Condylomata acuminata) on or around the genitals and anus. For example, HPV types 6 and 11 cause 90% of all genital warts. HPV types 6 and 11 also cause recurrent respiratory papillomatosis, a less common disease in which benign tumors grow in the air passages leading from the nose and mouth into the lungs while High-risk HPVs, which can cause cancer. About a dozen high-risk HPV