IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 18, Issue 11 Ser.10 (November. 2019), PP 01-09 www.iosrjournals.org DOI: 10.9790/0853-1811100109 www.iosrjournals.org 1 | Page Outcome Analysis Of Splenectomy In Paediatric Patients With HIV, Hepatitis B, Hepatitis C Either Singly Or In Combination- A Prospective Study Dr. Biswajoy Roy 1 , Dr. Indranil Chatterjee 2* , Prof. Sukanta Kumar Das 3 1 Principal medical Officer, Ordnance factory Hospital, Ishapore, West Bengal. 2* Associate Professor, Department of Pediatric Surgery, Medical College, Kolkata. 3 Professor & HOD, Department of Pediatric Surgery, Medical College, Kolkata. Corresponding Author: Dr. Indranil Chatterjee Abstract Introduction: Spleen is an essential organ in the body for its haematopoietic, immunological and scavenger action. It is seen that those persons without spleen –either congenitally or spleen removed anytime later in life for any reason are facing many problems- one of them is depressed immunity. Splenectomised patients have all range of infections- starting from minor chest or urinary tract or wound infection to life threatening OPSI, leading to increased morbidity and mortality- seen in both paediatric as well as adult patients. Materials and Methods: Immunocompromised patients(with HIV, Hepatitis B, Hepatitis C infection) with splenomegaly and sero negative cases with splenomegaly who needed splenectomy for any reason attending Pediatric Surgery OPD and admitted to Paediatric Surgery department of MCH for splenectomy. Total number of patients with immunocompromization and splenomegaly admitted to paediatric surgery Department of MCH during our study period,was 25 cases .We have considered 25 sero negative cases who had undergone splenectomy for any indication during this period, as the control group. Results: Our present study did not show any evidence that splenectomy in sero positive cases caused so much immuno suppression that the patients became very much prone to clinically evident major/ overwhelming infection. Vis a vis, complication rates were found to be insignificant/almost comperable in these two groups. Conclusion: So, based on the above facts of this study, we conclude that neighthor chronic Hepatitis B, Hepatitis C, HIV-either singly or in combination have any clinically or statistically significant adverse effect on post-operative outcome of splenectomy patients, nor splenectomy causes acceleration or aggravation of natural history of these chronic diseases. Key Words: Spleen, OPSI, HIV, Hepatitis, mortality, morbidity --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 07-11-2019 Date of Acceptance: 23-11-2019 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Spleen is an essential organ in the body for its haematopoietic, immunological and scavenger action. It is seen that those persons without spleen –either congenitally or spleen removed anytime later in life for any reason are facing many problems- one of them is depressed immunity. Splenectomised patients have all range of infections- starting from minor chest or urinary tract or wound infection to life threatening OPSI, leading to increased morbidity and mortality- seen in both paediatric as well as adult patients. Paediatric patients being more susceptible to infection due to their less innate immunity as compared to their adult counterpart will be further at risk if their spleen is also sacrificed due to any reason. So far as immunological functions are concerned, spleen contributes to both cellular as well humoral immunity. The aim of our study is to explore the effect of sero positivity on the post operative outcome of splenectomy in terms of complications and also to find if splenectomy at all accelerates the natural history of Hepatitis B,C and HIV- if the patients happened to be sero positive pre-operatively. II. Materials And Methods Study Area: Department of Paediatric Surgery, Medical College & Hospital, Kolkata. Study population: Immunocompromised patients(with HIV, Hepatitis B, Hepatitis C infection) with splenomegaly and sero negative cases with splenomegaly who needed splenectomy for any reason attending Pediatric Surgery OPD and admitted to Paediatric Surgery department of MCH for splenectomy. Study period: January 2016 to December 2017.