IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 18, Issue 12 Ser.3 (December. 2019), PP 05-08 www.iosrjournals.org DOI: 10.9790/0853-1812030508 www.iosrjournals.org 5 | Page Dental Management of Ectodermal Dysplasia: A Case Report *Elena Petrova 1 , Sanja Panchevska 2 , Meri Pavleska 3 , Iva Manevska 4 , Ivan Dimovski 5 ,Vesna Fiser 6 1 Department of orthodontics, Faculty of dentistry, Skopje, Macedonia 2 Department of prosthodontics, Faculty of dentistry, Skopje, Macedonia 3 Department of pedodontics, Faculty of dentistry, Skopje, Macedonia 4 Richmond Orthodontics, London, UK 5 Private Dental Practice KALE, Skopje, Macedonia 6 Private Dental Practice JANKULOVSKI, Skopje, Macedonia Corresponding Author:*Elena Petrova Abstract Aim: To present a case report of an interdisciplinary treatment of young patient with ectodermal dysplasia associated with severe oligodontia Material and method: This report presents a case of a 9 year old child affected by ectodermal dysplasia with hypodontio in the upper jaw, atypically located maxillary canines and edentulism in the lower jaw. Treatment of thos patient was interdisciplinary including an orthodontics, prothodontics and pedodontics. Results: Conservative and prosthodontic treatment made significant imporevement of the extraoral profile as well as intraoral aesthetics. Beside that improvement in masticatory function and speech was also noticed after the treatment. The results had major impacts on self-esteem, masticatory function, speech and facial esthetics. Conclusions: Interdisciplinary management and communication of different specialties has once again proved to be essential in treatment of dental problems in complex cases such as ectodermal dysplasia. Keywords:hypodontia, anodontia, oral rehabilitation, removable prosthesis --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 25-11-2019 Date of Acceptance: 10-12-2019 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Ectodermal dysplasia is a hereditary disorder associated with abnormal development of embryonic ectodermally-derivated organs including teethe,nails and sweet glands. It can be inherited in any form of several genetic patterns including autosomal-dominant, autosomal-recesive, and X-linked modes. These gene abnormalities can be inherited from one or both parents, or they can arise as a new genetic event. Althought more than 170 different subtypes of ectodermal dysplasia have been identified, these disorders are considered to relatively rare with an estimated incidence of 1 case per 100 000. The most common form of ectodermal dysplasia ussually affects men. Other forms od the disease affects men and women equallly. According to the state of sweat glands involvment, two major groups are distinguished: hypohidrotic or anhydrotic ( Christ-Siemens –Touriane syndrome ) in which sweat glands are absent or significantly reduced in number, or hydrotic ( Cloustone Syndrome ) in which sweat glands are normal. The hypohidrotic as the most common type seems to show X-linked inheritance pattern, therefore males are more susceptible than females. On the other hand hydrotic type is inherited in an autosomal dominant pattern. Prenatal diagnosis is available for some families with X-linked hypohidrotic dysplasia through the use of DNA probes. This is not possible for all families. The teeth are markedly reduced in number (oligodontio or hypodontio). And often manifest abnormal development in shape which may appear tapered, conical or pointed in incisors/. Molars might be observed in reduced size. The lack of tooth bud formation causes hypoplastic alveolar bone, leading to reduced vertical dimension of occlusion. Therefore an old appearance is common in affected individuals. There is no specific treatment for this disorder. But here are some usefull recomandations in such cases: wearing a wig or dentures to improve appearance, using artificial tears to replace normal tearing and prevent drying of the eyes, spraying the nostrils with saline nose spray often to remove debris and prevent infection., living in cooler climate and taking cooling water baths or using water sprays to keep a normal body temperature . A new treatment that could help children born with a rare genetic condition has been developed at the Washington University School of Medicine in Misuri, The new treatment which is in clinical trail now, is a recombinant protein that initiates a cascade of molecular and cellular events that leads to the proper