Karim et al., J Adv Biotechnol Exp Ther. 2020; 3(1): 49-55 www.bsmiab.org/jabet 49 Hypoglycemic and antidyslipidemic potential of Pleurotusostreatus in streptozotocin-induced diabetic rats Md. Rezaul Karim 1* , Md. Foyzur Rahman 1 , Md. Rezanur Rahman 1 , Zinat Tamannaa 1 , Dipayon Krisna Ghose 2 , Md. Nurul Islam 3 , Md. Tofazzal Hossain 2 , Rokibul Islam 4, 5 , Md. Ataur Rahman 5* 1 Department of Biochemistry and Biotechnology, KhwajaYunus Ali University, Enayetpur, Sirajganj, Bangladesh. 2 Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh. 3 Department of Zoology, University of Rajshahi, Rajshahi, Bangladesh. 4 Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, Bangladesh. 5 Global Biotechnology & Biomedical Research Network (GBBRN), Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, Bangladesh. * Corresponding author: Md. Rezaul Karim, email: rezaul929@gmail.com and Md. Ataur Rahman, email: ataur1981rahman@hotmail.com Academic Editor: Dr. Md Nabiul Islam, Yamaguchi University, Japan. Received: 23 October 2019; Accepted: 11 December 2019; Published: 16 January 2020. ABSTRACT: Oyster Mushroom (Pleurotusostreatus), an edible mushroom, is traditionally being used as a curing. However, hypoglycemic as well as antidyslipidemic effects on methanolic and ethyl acetate extracts of oyster mushroom in streptozotocin-treated diabetic rat model was not investigated yet. Here, we investigated that oral administration of 200 mg/kg oyster mushroom for 30 days were estimated through evaluating the fasting blood glucose level and blood lipid profile of diabetic rat. The results from our studies explained that P. ostreatusoyster mushroom considerably decreased blood glucose level initiated after treatment on second week. However, oyster mushroom was significantly reduced in plasma triglycerides (TG), total cholesterol (TC), as well as low-density lipoprotein-cholesterol (LDL-C). Additionally, high density lipoprotein-cholesterol (HDL-C) was enhanced by the treatment of oyster mushroom. Therefore, the current study suggests that P. ostreatus has antihyperglycemic and anti- dyslipidemic effect on streptozotocin-induce diabetic rat model. KEYWORDS: Pleurotusostreatus, anti-hyperglycemic, antidyslipidemic, blood glucose level, lipid profile. INTRODUCTION Diabetes mellitus (DM), a metabolic disease, is described as a hyperglycemia, damaged glucose, lipids, and proteins metabolism [1]. Generally, insulin deficiency causes this disorder [2]. Around 220 million people globally affects in this disease and this will be double in the year of 2030 [3]. Oxidative stress which cause lipid peroxidation as well as tissue injury comprising nephropathy, retinopathy, in addition exhibit coronary heart disease as well [4,5]. Additionally, hyperlipidemia or dyslipidemia are intricate in the improvement of cardiovascular problems with a major effect of mortality as well as morbidity [6]. However, traditional food constituent that may decrease glucose absorption or appetite in hepatic gluconeogenesis, intestine, body weight, blood glucose level, in addition to stimulate glucose prompted insulin secretion from pancreatic beta-cells might demonstrated for prevention as well as control of diabetes mellitus. Thus, a diversity of plants could be used in the administration and management of DM, even though their biologically active constituents are unknown yet [7]. To elucidate the effect of oyster mushroom, Pleurotusostreatus, on hyperglycemia as well as dyslipidemia in streptozotocin (STZ)-induced diabetic rat model is investigated in this studies. As we concern that mushrooms are less calories food but highly proteins enriched, carbohydrates, fibers, and vitamins for example, Vit-B complex, Vit-C and minerals [8-12]. From numerous studies it has been well known that the daily mushroom consumption is beneficial effect to health and is usually considered it as a functional foods [13-14]. It has been found that mushroom comprises ORIGINAL ARTICLE J Adv Biotechnol Exp Ther. 2020; 3(1): 49-55 eISSN: 2616-4760, https://doi.org/10.5455/jabet.2020.d106 Published by www.bsmiab.org