ACTA SCIENTIFIC MICROBIOLOGY Volume 2 Issue 5 May 2019 Concerns on Control Measures for Methicillin-Resistant Staphylococcus Aureus Colonization Dissemination in Long-Term Care Facilities: A Meta-Analysis and Systematic Review Victor Lage de Araujo 1* , Ana Claudia Paradella Freitas 2 , Elaine Coutinho Neto 2 and Marilene Conceição Felix da Silva 3 1 Physician, Infection Control Specialist, Unit of Infection Control, The SARAH net of Rehabilitation Hospital, MSC Evidence-based Healthcare, International Fellow, College of American Pathologists 2 Physician, Infection Control Specialist, Unit of Infection Control, The SARAH net of Rehabilitation Hospitals Salvador, BA, Brazil 3 Librarian, MSc, The SARAH net of Rehabilitation Hospitals Library, Salvador/BA, Brazil *Corresponding Author: Victor Lage de Araujo, Department of Clinical Laboratory/Infection Control Unit, The Sarah Hospital of Rehabilitation, Brazil. E-mail: victor.araujo.15@ucl.ac.uk Research Article Received: March 06, 2019; Published: April 18, 2019 Abstract Keywords: MRSA; Meta-Analysis; Systematic Review; Long-term Care Facilities; Epidemiology; Prevention and Control Methicillin-Resistant Staphylococcus Aureus (MRSA) can cause colonisation and infection in anatomical sites such as the nares, axillae, groin. Sepsis, pneumonia, skin and other diseases can result. Three individualised strains exist: Hospital-Associated, Community-Associated and Livestock-Associated (HA-MRSA, CA-MRSA, LA-MRSA). Healthcare Workers (HCW) are apprehensive about the spread of MRSA. Hospital administrators and Healthcare authorities express concern about Multi-Resistant Organisms (MRO) and dictate control measures. In Long-term Care Facilities (LTF), Infection Control Professionals (ICP) are required to balance the risk of propagation of MRO with the adverse effects of measures on healthcare and rehabilitation programs. One must consider their potential pitfalls – such as the overuse of antibiotics, selective pressure to the hospital flora and intrusion on care and rehabilitation programs – against desired effects. Patients in LTF feature an extended stay, while not being actively sick. Some measures against MRSA may be ineffective or even detrimental to those patient’s care and rehabilitation. We present the first comprehensive bibliography review concerning measures against MRSA in LCF. We searched multiple databases, with no language limits, with the objective to evaluate the effectivity of all actions against MRSA. We analysed 7 Randomised Control Trial (RCT) studies (out of 539 records found). We assessed the bias of studies according to the Cochrane methodology. We calculated the Risk Ratio (with a fixed effect) of the Prevalence of MRSA using Revman and made a Meta-analysis of the studies. None of the RCT showed evidence of the effect of the measures studied against MRSA prevalence. We conclude there is no evidence of efficacy of any measures on the Prevalence of MRSA in LCF. Studies evidence that some procedures are not cost-effective and obstacle rehabilitation. LCF need to accordingly re-evaluate routines against MRSA to minimise both unnecessary and ineffective procedures. After cost-effectivity evaluation of unfavourable effects, it is advisable to stop using unnecessary measures. We did not find RCT studying the Quality of Life (QOL) of patients. Further studies are necessary to establish the interference of measures on the QOL of rehabilitation patients. Citation: Victor Lage de Araujo., et al. “Concerns on Control Measures for Methicillin-Resistant Staphylococcus Aureus Colonization Dissemination in Long-Term Care Facilities: A Meta-Analysis and Systematic Review”. Acta Scientific Microbiology 2.5 (2019): 66-93.