International Journal of Advanced Scientific and Technical Research Issue 3 volume 4, July-August 2013 Available online on http://www.rspublication.com/ijst/index.html ISSN 2249-9954 R S. Publication, rspublicationhouse@gmail.com Page 257 HEPATOPROTECTIVE ROLE OF SPIRULINA AGAINST CCL 4 INDUCED LIVER ALTERATIONS IN RATS: A COMPARATIVE STUDY Dr. M. Vijaya Bhaskara Reddy * , T. Monika, P. Sasikala., Department of LPM, College of Veterinary University, Sri Venkateswara Veterinary University, Tirupati, India. +91-7396120530,+91-9705497313 Dept. of Animal Nutrition, College of Veterinary University, Sri Venkateswara Veterinary University, Rajendra Nagar, India. +91-9052224389 ______________________________________________________________________________ Abstract: Spirulina is microscopic blue green algae. spirulina belongs to cyanophyceae a procaryotic form. Present research work is to evaluate the hepatoprotective activity of spirulina. Comparative evaluation of hepatoprotective activity of petroleum ether, chloroform and methanol extracts of spirulina against carbon tetrachloride induced hepatotoxicity based on the biochemical parameters. All the test extracts administered orally for a period of 10 days showed significant hepatoprotective activity. Keywords: spirulina, hepatotoxicity, Hepatoprotective activity, phycocyaxin, phycoerythrin. ______________________________________________________________________________ Introduction: Spirulina is simple microscopic blue green algae. It belongs to cyanophyceae a procaryotic form. The photosynthetic pigment phycocyanin and phycoerythrin makes it to be included in cyanophycean algal group. But the nature of it’s nucleus (procaryotic) engrauped it in as a procaryotic organism a cyanobacterium. In other wards spirulina is a photosynthetic procaryotic microorganism and grows naturally in fresh, brakish sewage water and even in saline environment. It grows through photosynthesis, hence it can be termed as vegetative food. It has already been affectively promoted as a natural food. Spirulina is a natural package of protein, vitamins and minerals. The experimental intoxication induced by ccl 4 is widely used for modeling liver injury in rats. Village folk use, spirulina in liver