International Journal of Advanced Scientific and Technical Research Issue 3 volume 2, March-April 2013 Available online on http://www.rspublication.com/ijst/index.html ISSN 2249-9954 Page 528 STUDY ON EFFECT OF SODIUM SELENITE ON PHYSIOLOGICAL AND HEMATOLOGICAL ALTERATIONS INSWISS ALBINO MICE Dr. M. Vijaya Bhaskara Reddy * and P. Sasikala Corresponding author: Dr. M. Vijaya Bhaskara Reddy Study Investigator Pfizer Project, Dept. of LPM College of veterinary Science Sri Venkateswara Veterinary University Tirupati-517502 Andhra Pradesh, India Cell: +91-7396120530 Co- Author: P. Sasikala Dept. of LPM College of veterinary Science Sri Venkateswara Veterinary University Tirupati-517502 Andhra Pradesh, India ________________________________________________________________________________________________________ ABSTRACT: The present study was designed to evaluate the effects of sodium selenite on the antioxidative activities of neutrophils and the hematological parameters in mice. Forty eight mice were randomly allocated into two groups. Group 1 served as the control and 2 orally received at sodium selenite at 1 mg Se/kg for 10 consecutive days. To assess the degrees of oxidative stress and of lipid peroxidation of the cellular membranes, the levels of thiobarbituric acid reactive substances (TBARS) were determined in serum samples those were collected at different supplementation intervals, i.e. 0, 10, 20, and 30 th day of experimentation. In addition, hematological parameters in the serum samples were measured by routine procedures. It was found that TBARS level in group 2 were significantly higher on days 20 and 30 compared to the basal level on day 0. It was also found that on day 30, the activity of TBARS in the treated group were significantly higher than those of the controls ( P < 0.05). These findings may explain the seemingly paradoxical effects of supplemental selenium on the indicators of oxidative stress, as the levels of TBARS were generally expected to decrease in the presence of selenium. There