International Journal for Research in Applied Science & Engineering Technology (IJRASET) ISSN: 2321-9653; IC Value: 45.98; SJ Impact Factor: 7.177 Volume 8 Issue I, Jan 2020- Available at www.ijraset.com © IJRASET: All Rights are Reserved 723 Some Approved Medicines containing Benzimidazole Moiety: A Mini Review Dr. Navneet Singh 1 , Dr. Pradeep Kumar 2 1, 2 Chemical sciences, Applied Science and Humanities, Roorkee College of Engineering, Roorkee, Uttarakhand, India-247664 Abstract: Benzimidazole derivatives are of wide interest because of their presence in numerous categories of medicinal drugs; such as anticancer, anticoagulants, antihypertensives, anti-inflammatory, antimicrobials, antiparasites, antivirals, antioxidants, immunomodulators, proton pump inhibitors, hormone modulators, CNS stimulants as well as depressants, lipid level modulators, antidiabetics etc., makes it a moiety of great importance in medicinal chemistry. Because of this great importance, it attracts the researchers to synthesize more effective benzimidazole derivatives for several biological activity screening. Keywords: Benzimidazole; moiety ; medicinal drugs; antiparasites ; biological activity; I. INTRODUCTION The benzo derivative of imidazole is referred to as benzimidazole. [1] Although benzimidazole is the commonest name of the parent compound of the series, other names such as benzimidazole and 1,3-benzodiazole are often used. N H N 1 2 3 4 5 6 7 8 9 In 1872, Hoebrecker synthesized benzimidazole first time as 2, 5- or 2, 6-dimethylbenzimidazole (tautomers) through reduction of 2-nitro-4-methylacetanilide in presence of Sn/HCl reducing agent. [2] After Hoebrecker, in 1875 Ladenburg extensively explored the benzimidazole synthesis by condensation between O-amino aniline and carbonyl compounds (aldehyde and ketone) and others by using. [3] . Subsequently, Phillips explored Ladenburg synthesis to the condensation between O-amino aniline and carboxylic acids (acetic acid). Hence the synthesis reaction of benzimidazole from O-amino aniline is known as Ladenburg synthesis or Phillips synthesis or Ladenburg – Phillips synthesis. [4] Active involvement of benzimidazole nucleus reported in various therapeutic agents like antiparasitics, anticonvulsants, analgesics (Etonitazene), antihistaminics (astemizole), antihelmintics (albendazole, mebendazole, thiabendazole), antiulcers, antihypertensives (candesarten cilexitil, telmisartan), antiviral (enviradine), anticancers, antifungals (Benomyl, Carbendazim), anti-inflammatory agents, proton pump inhibitors (omeprazole, lansoprazole, pantoprazole) and anticoagulants. [5] In this review letter, some approved medicines will be discussed. A. Some Benzimidazole Drugs Albendazole (albendazolum) [CAS Number- 54965-21-8] is used for various parasitic worm infections. It is useful for giardiasis, trichuriasis, filariasis, neurocysticercosis, hydatid disease, pinworm disease, and ascariasis, among others. It is taken by mouth. [6] Mebendazole (MBZ) (CAS Number- 31431-39-7) is a medication used to treat a number of parasitic worm infestations. This includes ascariasis, pinworm disease, hookworm infections, guinea worm infections, hydatid disease, and giardia, among others. It is taken by mouth. [7] N H N NH O O S N H N NH O O C O Albendazole Mebendazole