Journal Pre-proof Rediscovery of natural compounds acting via multitarget recognition and noncanonical pharmacodynamical actions Mariano Bizzarri, Alessandro Giuliani, Noemi Monti, Roberto Verna, Andrea Pensotti, Alessandra Cucina PII: S1359-6446(20)30080-5 DOI: https://doi.org/10.1016/j.drudis.2020.02.010 Reference: DRUDIS 2642 To appear in: Drug Discovery Today Please cite this article as: Bizzarri M, Giuliani A, Monti N, Verna R, Pensotti A, Cucina A, Rediscovery of natural compounds acting via multitarget recognition and noncanonical pharmacodynamical actions, Drug Discovery Today (2020), doi: https://doi.org/10.1016/j.drudis.2020.02.010 This is a PDF ﬁle of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the deﬁnitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its ﬁnal form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2019 Published by Elsevier.