_____________________________________________________________________________________________________ *Corresponding author: E-mail: haatscific@gmail.com; Asian Journal of Biochemistry, Genetics and Molecular Biology 3(2): 1-8, 2020; Article no.AJBGMB.53866 ISSN: 2582-3698 Modulatory Effects of Some Fruit Juices on Lipid Profile in Rats Fed with High Lipid Diet Habibu Tijjani 1* , Enoch Banbilbwa Joel 2 and Carrol Domkat Luka 2 1 Department of Biochemistry, Faculty of Science, Bauchi State University, Gadau, Nigeria. 2 Department of Biochemistry, Faculty of Medical Sciences, University of Jos, Jos, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Authors HT, CDL and EBJ designed the study, performed the statistical analysis and wrote the protocol. Author HT wrote the first draft of the manuscript and managed the analyses of the study. Authors HT, EBJ and CDL managed the literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/AJBGMB/2020/v3i230079 Editor(s): (1) Dr. Ahmed Medhat Mohamed Al-Naggar, Professor, Department of Agronomy, Faculty of Agriculture, Cairo University, Egypt. Reviewers: (1) Tabe Franklin Nyenty, University of Yaounde 1, Cameroon. (2) Nebi Bilir, Suleyman Demirel University, Turkey. Complete Peer review History: http://www.sdiarticle4.com/review-history/53866 Received 06 November 2019 Accepted 11 January 2020 Published 16 January 2020 ABSTRACT Background: Hyperlipidemia is a predisposing factor to several cardiovascular diseases, including atherosclerosis, myocardial infarction, heart attacks and others. Aim: This study investigate the hypolipidemic properties of five selected fruits using rats pre-fed with High Lipid Diet (HLD) under experimental conditions. Methods: Raw fruit juices from Guava (Psidium guajava), Pawpaw (Carica papaya), Banana (Musa acuminata), Apple (Pyrus malus) and Pineapple (Ananas comosus) respectively, were administered orally at a dose of 7 ml/kg body weight for 14 days. Sera from the experimental rats were prepared for total cholesterol (TC), triglyceride (TG), High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL) assay, while Very Low Density Lipoprotein (VLDL) and Atherogenic Index (AI) were computed. Results: Feeding the experimental rats with High Lipid Diet increased their levels of TC, TG, LDL, VLDL and AI by 68.73%, 72.94%, 20.23%, 71.79% and 208.72% respectively with a corresponding decrease in HDL by 29.47%. Pineapple juice significantly reduced the levels of TC, TG, LDL, VLDL Original Research Article