Acta Medica Mediterranea, 2020, 36: 1129 CANCER BIOMARKERS IN HIV-INFECTED PATIENTS WITH AND WITHOUT DRUG ADDICTION LYUDMILA L. AKHMALTDINOVA 1 , ILYA S. AZIZOV 2 , ZOYA P. TYUKHTINA 3 , LUBOV I. SERDYUK 3 , NADEZHDA V. KOZACHENKO 4 , TIM SANDLE 5 , DAN MORARU 7 , ANTONELLA CHESCA 6, 7 1 Karaganda State Medical University, Kazakhstan - 2 Institute of Antimicrobial Chemotherapy, Smolensk, Russia - 3"Karaganda Re- gional Center for the Prevention and Control of AIDS" Karaganda, Kazakhstan - 4 Non-governmental Public Association “Credo”, Karaganda, Kazakhstan - 5 The University of Manchester, United Kingdom - 6 Transilvania University of Brasov, Romania - 7 Clinical Hospital of Pneumophtysiology Brasov, Romania ABSTRACT Introduction: Pathogenesis of the connection of HIV-infection and cancer is a problem for medical professionals and presents an interesting area for research. The aim of the study was to investigate the level of cancerbiomarkers in HIV-infected patients with a background of narcotic drugs use, via parenteral administration, and in HIV-infected patients without a similar background. Materials and Methods: We analyzed the serum from 30 HIV-positive injecting drug users and30 HIV-positive patients without drug addiction. A control group consisted of 30 healthy people (negative in screening for HIV-infection) and a comparison group of 23 patients with drug dependence but no HIV-infection. We used the xMap method on Bioplex 3D with a set cancer biomarkers panel: sHER-2, sEGFR, sIL-6Rα, FGF, sVEGFR-2, PECAM1, PDGF AB/BB, G-SCF, sTIE2, SCF, sVEGFR-1, osteopantin. Results: The research revealed the increased levels of sHER-2, sEGRf, sIL-6RA, sVEGfr2, PECAM1, sTIE2 in all HIV-infected patients. SCF and FGF markers were increased only in injecting drug users (HIV+/HIV-). The drug addicts with HIV had the increased level of inflammatory markers sIL-6RA, PECAM 1, osteopantin and the level of HER-2. Conclusion: This study of carcinogenesis biomarkers showed its own peculiarities in HIV-positive patients, including complica- tions for those with drug addiction. Keywords: HIV, cancer, drug addiction, cancerbiomarkers. DOI: 10.19193/0393-6384_2020_2_173 Received November 30, 2019; Accepted January 20, 2020 Background The classical, clinical picture of AIDS is characterized by the development of proliferative disorders, but in most cases it concerns virus- associated oncological diseases (Kaposi's sarcoma and lymphoma). Currently, there is accumulating evidence that HIV-infection promotes increased incidence of cancer even with the timely reception of effective retroviral drugs (1-3) . Is leads to the research question: whether this is related to HIV-infection or if it is it a consequence of social disadvantage and the toxic effects of extraneous drug-linked factors? The question is still open. Only recently has the data appeared that suggests oncogenes are involved in the intracellular persistence of HIV (4) , but these issues are still being discussed, opening up new horizons for the study and research of therapeutic strategies of HIV-infection. The study of the effectiveness of social and preventive drug-use and the fundamental problems of interaction between the virus and the immune system will help to develop new effective approaches to HIV/AIDS. The aim of the study was to investigate the level of molecular cancer biomarkers in HIV-infected patients with parenteral forms of narcotic drugs without an aggravating background.