European Scientific Journal March 2020 edition Vol.16, No.7 ISSN: 1857 – 7881 (Print) e - ISSN 1857- 7431 157 Interventions, Entrepreneurial Orientation and Macro Environment: Effect on Beneficiary Poverty Reduction by Faith Based Enterprises Nalyanya N. Charles, PhD candidate, Bitange Ndemo, PhD, Professor of Entrepreneurship, School of Business, University of Nairobi, Kenya James M. Gathungu, PhD, Senior Lecturer Strategy and Entrepreneurship, School of Business, University of Nairobi, Kenya Ganesh P. Pokhariyal, PhD, DSc. Professor of Applied Mathematics, School of Mathematics, University of Nairobi, Kenya Doi:10.19044/esj.2020.v16n7p157 URL:http://dx.doi.org/10.19044/esj.2020.v16n7p157 Abstract This study focuses on joint effect of interventions, entrepreneurial orientation and macro environment on beneficiary poverty reduction (BPR) by Faith based enterprises (FBEs) within the slums of Nairobi, Kenya. In Nairobi, about 60-70% of the people live in slums and conditions are deplorable. Hence, FBEs assist meet the social welfare voids like shelter, water, health services, education and employment. However, there is distorted and incomplete information with divergent views to explain success or failure of joint effects in BPR. Hinged on these gaps, the study objective of joint effect of the variables on BPR is assessed and its hypothesis is tested. The study uses a census approach and data was collected from 72 FBEs using a structured questionnaire. The study uses the descriptive cross-sectional research design and data is analysed using descriptive statistics and hierarchical multiple regression analysis. Study found that joint effect of the variables has a greater effect on BPR than the singular effect of each variable; most people in Nairobi slums live below World Bank poverty threshold of $1.90 per day and FBEs bring disruptions that create wealth enabling people take charge of their own destinies as they escape from poverty. Key hindrances to BPR in the slums of Nairobi include lack of markets, reduced donor funding, basic needs such as food, water, shelter, health services, public schools, latrines for safe hygiene and unemployment. Study adds value to theory as findings show net works trigger the mobilization of resources which