Singh Manjeet, Bhambhani Lavina Pratap; International Journal of Advance Research, Ideas and Innovations in Technology © 2020, www.IJARIIT.com All Rights Reserved Page |661 ISSN: 2454-132X Impact factor: 6.078 (Volume 6, Issue 2) Available online at: www.ijariit.com Alternatives to mitigate Corona Manjeet Singh monurao18@gmail.com Parul University, Vadodara, Gujarat Lavina Pratap Bhambhani lavinabhambhania1@gmail.com Parul University, Vadodara, Gujarat ABSTRACT Coronavirus is most pandemic virus and it is challenging too for the scholars and scientists to discover its vaccine. Like every organism in nature struggling for survival, they evolve or mutate. Similarly, the coronavirus has changed its genome sequence to adapt to the new species. In fact, research has shown COVID-19 has mutated repeatedly in ways to boost its survival which results in more difficulties to discover its vaccine. We can’t hit the coronavirus directly and neither our immune system is capable enough to fight with it, but by killing the infected cells, we can kill the corona virus too. Keywords⸻ Multiplicity of infection (MOI), P. falciparum, Bilirubin Synthesis, CQ Heme Complex, SARS 1. HISTORY Scientist first identified a human corona-virus 1965. Corona viruses are a big family of different viruses. Some of them cause the common cold in people, other infects animals including bats, camels and cattle. Symptoms included fever, dry cough, dyspnea, diarrhoea, sore throat, ventilator use, breathing problems, shortness of breath etc. The SARS emerged in southern china in 2002 and quickly spread to 28 other countries. More than 8000 people were infected by July 2003, and 774 died. A small outbreak in 2004 involved only 4 more cases. MERS started in Saudi Arabia in 2012, almost all of the nearly 25000 cases have been in people who live in or travel to Middle East. In December 2019, COVID-19 came into existence from Wuhan, china. Till today it has infected approximately 26.53 lakh people and caused the death of around 2.18 lakh people and these numbers are increasing exponentially every day. 2. INTRODUCTION The group of viruses which can cause mild to lethal effects on mammals and birds are called corona viruses. It causes severe infections in respiratory tract and some common cold like symptoms in mammals (including humans) and birds. Corona virus is one of the largest RNA based virus causing lethal effects in humans, other mammals and birds. It has large pleomorphic spherical particles with bulbous surface projections. The average diameter of viruses is around 120nm and the envelope layer is made up of lipid bilayer and is around 80nm in diameter. Inside the envelope the nucleocapsid which are bound to RNA genome. Source: https://www.scientificanimations.com/wiki-images/ The Spike (S) protein in virus can binds with the cellular receptors present on the cell surface including ACE-2, GRP78 and CD147 to gain access into the cell. After setting foot into the cell, virus manipulates the mechanism of cell for making replicas of itself. Usually our immune system molds up antibodies to disable the access of any virus to the receptors but in case of covid-19, our immune system is unable to develop antibodies and to develop a vaccine of it we have to go through a long process which may take months or years so we have to work on new methodologies to fight with these viruses.