Review Article Volume 14 Issue 3 - July 2019 DOI: 10.19080/CTOIJ.2019.14.555886 Cancer Ther Oncol Int J Copyright © All rights are reserved by Abhimanyu Kumar Jha Apoptosis Caused by Natural Compounds in Cervical Cancer Cell Line Deepa, Sweta Pal, Harsh Goel and Abhimanyu Kumar Jha* Department of Biotechnology, Faculty of Life Sciences, Institute of Applied Medicines & Research, India Submission: June 24, 2019; Published: July 10, 2019 * Correspondence Author: Department of Biotechnology, Faculty of Life Sciences, Institute of Applied Medicines & Research, Ghaziabad, Uttar Pradesh, India Cancer Ther Oncol Int J 14(2): CTOIJ.MS.ID.555886 (2019) 001 Cancer Therapy & Oncology International Journal ISSN: 2473-554X Introduction Cancer is a type of disease that spreads due to uncontrolled of cell growth due to the collection of defects or variation in their DNA and with imminence to attack or distribute to other parts of the body. Cancer is specified as a wide group of several infections normally characterized by persistently uncontrolled and unnatural at usual cell yield, where cell proliferation comes via mitotic deregulations and thus contributes to overgrowth of cancerous cells. In the case of malignancy, these cells may transmigrate from one body parts to other in the form of tumors and metastasis in blood stream sand lymphatic system (Ochwang et al., 2015 and Srivatava et al., 2015). Various studies have demonstrated that the cancer danger at the level of particular organs is due to exposure to particular environmental chemicals, biological factors (as Human Papilloma virus, Helicobacter hepticus, HIV1, HBV) or physical factors (such as X-radiation, gamma radiation) (Zulkipli et al., 2015). Research proposes that most malignancies are caused by a dysfunction of multiple genes coding for macromolecules like as growth factors, growth factor receptors, anti-apoptotic proteins, transcription factors, and tumor suppressors, all of which establish the aim for disease treatment (Cogliano et al., 2011 and Vogelstein et al., 2004). Cervix cancer is one of the numbers of cancer, which are second main origin of cancer deaths in women worldwide. At least 500,000 patients are diseased yearly those are suffering from cervical cancer in the developing world ( North et al., 2007). In 2006 there were generally 9710 new diseases and approximately 3700 deaths in United States (Atlanta et al., 2008). A persevering human papilloma virus (HPV) infection is a requirement for the growth of precursor lesions and invasive cervical carcinoma. Invasive cervical malignancy has a long premalignant phase termed cervical intraepithelial neoplasia (CIN). The preserve development from HPV infection to CIN and invasive disease generate CIN an excellent aspirant for chemo prevention (Alvarez et al., 2003). Cervical carcinoma is a disease that development quite slowly and starts with the precancerous condition called as dysplasia. Dysplasia is readily identified in a regular Pap smear and is absolutely treatable. Cervical carcinoma is a lethal malignancy obtains from the cells of the cervix. Due to programmed cell death, in a day approximately 50 and 70 billion cells lose in average adult human (Mitchell et al., 1995). Infection with the common human papillomavirus (HPV) is a cause of approximately 90% of all cervical carcinoma. About half of the sexually transmitted HPVs are companion with cervical carcinoma. Many reports have been summarized epidemiologically and experimentally on natural compound and its relation to prevention of cancer (Johnson et al., 2005), especially in relation to tea Compound and its effect on cervical carcinogenesis (Ahn et Abstract Cancer is a life-threatening disease involving out-of-control of cell growth in a mammalian body, these are of many types like (liver cancer, cervical cancer, skin cancer, breast cancer) There are many types of therapies available those are effective against cancer like (chemotherapy, radiotherapy). But these therapies are very painful and also cause some effect on healthy cells. Cervical cancer is one of the leading cancers caused by HPV (human papiloma virus) which mainly occur in women and after the age of 22 year the chance of cervical cancer increase. It is obtained from the cells of cervix. It can be detected through the regular Pap smear. But now days natural compounds are one of the best treatments to fight from the cancer because in natural compound many types of compounds are available those have capability to kill approximately 80% of the cancerous cells. Natural compounds include Quercetin, Eugenol, Green Tea, Genistein etc. which are known to be very effective against cervical cancer. Keywords: Cervical cancer; Human papilloma virus; Apoptosis; Quercetin; Eugenol