INTERNATIONAL JOURNAL OF CLINICAL VIROLOGY H J C V https://www.heighpubs.org/hjcv 023 https://doi.org/10.29328/journal.ijcv.1001010 Short Communication Vitamin D bring immunological protection in a pandemic response to Gripal viruses? A critical analysis Eliza Miranda Ramos 1-4 *, Francisco José Mendes dos Reis 1-3 , Hugo Vieira Ramos 2 , Igor Domingos de Souza 1-3 , Liliane de Mello Santos Bochenek 1,2 , Alessandro Carvalho da Fonseca 5 and Valter Aragão do Nascimento 1-3 1 Post Graduate Program in Health and Development in the Midwest Region, Dr. Hélio Mandetta Medical School, Federal University of Matogrosso do Sul, Campo Grande, MS, Brazil 2 Federal University of Matogrosso do Sul, Campo Grande, MS, Brazil 3 Laboratory of Mineral Metabolism and Biomaterials, Dr. Hélio Mandetta Medical School, Federal University of Matogrosso do Sul, Campo Grande, MS, Brazil 4 Brazil Foundation, CAPES, Brazil 5 Brazilian Hospital Services Company, UFGD, Brazil More Information *Address for Correspondence: Eliza Miranda Ramos, Post-Graduate Program in Health and Development in the Midwest Region, Dr. Hélio Mandetta Medical School, Federal University of Matogrosso do Sul, Campo Grande, MS, Brazil, Tel: +55**67-99948-0071; Email: elizamirandaramos@gmail.com Submitted: 16 March 2020 Approved: 06 April 2020 Published: 07 April 2020 How to cite this article: Ramos EM, Mendes dos Reis FJ, Ramos MV, de Souza ID, Bochenek LDS, et al. Vitamin D bring immunological protection in a pandemic response to Gripal viruses? A critical analysis. Int J Clin Virol. 2020; 4: 023-026. DOI: 10.29328/journal.ijcv.1001010 ORCiD: orcid.org/0000-0003-2683-636X Copyright: © 2020 Ramos EM, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Keywords: Immune system; Vaccine; Vitamin D; Flu OPEN ACCESS Introduction When carrying out an analysis over time in the history of pandemics such as the “Spanish Flu” it is possible to verify the high occurrence in the period from 1918 to 1920 [1]. For example, in the northern hemisphere, recent documents related to records of pandemic waves in the United States of America and Norway in the spring of 1918 in the months referring to February to April were mild and had low mortality, started in military populations and did not spread to civilian populations [1,2]. However, it was in the period of 1918 [1], speciϐically in the months of May to September, at that time morbidity occurred in a characteristically urban area in countries well connected with transport, in relation to rural areas it is possible to verify that isolated areas managed to have little pandemic incidence. But it was in the year 1919 [2], speciϐically in the months of January to March, that several isolated regions that had not previously had contagions were affected with devastating consequences [1,2]. Speciϐically in the year of the 1918 the H1N1 virus was responsible for pandemics during the winter and autumn wave periods in the United States [1]. What is observed in this period in relation to viral development is the presence of information regarding geographic factors and the host responsible with speciϐic patterns related to age and sex with morbidity, mortality and fatality per wave [1,2]. However, viruses have continued to emerge and bring challenges to the global public health system with emerging viruses with respiratory contagion, for example, in 2002 the coronavirus (CoV) of a viral family, known since the 1960s which is the cause of infection breathing in humans and animals has brought problems to human health [1]. Coronavirus causes mild to moderate respiratory illness and the symptoms are equivalent to a common cold. Generally the coronaviruses that infect humans are the alpha coronavirus 229E, NL63 and beta coronavirus OC43 and HKU1 types [3-7]. In addition, the coronavirus can develop as the disease worsens due to a genetic environmental depression of the Abstract In the evolutionary journey of humanity, it is possible to verify an analysis of pandemics with high occurrences. This study aims to conduct a critical analysis of the role of Vitamin D as an endogenous vaccine in the main viruses present in humanity over the decades. To construct this text, we used the short review methodology through a critical analysis. This study demonstrated the importance of using Vitamin D as an endogenous vaccine when used frequently in both healthcare professionals and patients. Therefore, it is concluded that Vitamin acts protectively in the innate immune system.