Int J Pharma Res Health Sci. 2020; 8 (2): 3139-42 3139 IIIIIIIII© International Journal of Pharma Research and Health Sciences. All rights reserved DOI:10.21276/ijprhs.2020.02.01 Kaur et al. CODEN (USA)-IJPRUR, e-ISSN: 2348-6465 Review Article A Review: Epidemics and Pandemics in Human History Harmanjot Kaur , Shashwat Garg *, Himanshu Joshi, Sumbul Ayaz, Surabhi Sharma, Maulshree Bhandari Invertis Institute of Pharmacy, Invertis University, Bareilly, Uttar Pradesh, India-243123. ARTICLE INFO ABSTRACT ______ 1. INTRODUCTION In communicable diseases enhance mortality rate [1] human beings are part of nature and we are not allowed to do anything wrong with nature if we do than it comes back to you in form of infectious diseases and many other disasters [2]. Epidemic is defined as appearance of diseases in area or population in excess [3] on other side pandemic is defined as epidemic which appears in wide range or area, spread to other countries and number of population suffer with it [4]. Epidemics and Pandemics like Small pox, Blackdeath, HIV/AIDS and many more diseases are most dangerous killers in human history [5].These diseases are caused by virus, bacteria, influenza etc [6]. With Justinian of Plague number of people lost their lives [2]. Middle East International Journal of Pharma Research and Health Sciences Available online at www.pharmahealthsciences.net Received: 04 Apr 2020 Accepted: 22 Apr 2020 Corresponding author * Shashwat Garg Invertis Institute of Pharmacy, Invertis University, Bareilly, Uttar Pradesh, India-243123. E-mail: Shashwat.g@invertis.org Infectious diseases greatly increase death rate in world population that dysfunction or breakdown social life, effect on economy. Nature powers are erratic. Therefore it is truer that some infectious diseases come without giving any warning by nature. The diseases which spread one person to other person in particular area, city very rapidly is known as Epidemics and the diseases which spread from one country to others known as Pandemic. Choleric plague, smallpox, AIDS and influenza etc. was very dangerous communicable diseases in past years ago and some are also present now like AIDS and COVID, it is the most devastating example of pandemics. Disease outbreaks are occurring when disease spread unexpectedly and rapidly. Epidemics and Pandemics damage to humans in few time. Keywords: Flu, Plague, HIV/AIDS, Virus, Pandemic, Epidemics, COVID.