IP Indian Journal of Clinical and Experimental Dermatology 5 (2019) 239–242 Content available at: iponlinejournal.com IP Indian Journal of Clinical and Experimental Dermatology Journal homepage: www.innovativepublication.com Original Research Article Study on serum copper, zinc and selenium trace element levels in Psoriasis Vijaya Mohan Rao 1, *, M Deepthi 1 , K Ramalingam 2 , M Prasad Naidu 2 , Mahaboob V. Shaik 3 1 Dept. of Dermatology, Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India 2 Dept. of Biochemistry, Narayana Medical College And Hospital, Nellore, Andhra Pradesh, India 3 Narayana Medical College and Hospital, Nellore, Andhra Pradesh, India ARTICLE INFO Article history: Received 13-06-2019 Accepted 20-08-2019 Available online 14-09-2019 Keywords: Psoriasis Zinc Copper Selenium P Value 0667 0266 ABSTRACT Introduction: Psoriasis is one of the skin disorder, mainly characterized by scaly papules and plaques. The etiology of psoriasis is multifactorial and still not properly understood. In our study, we tried to elucidate the relation between psoriasis and trace elemens namely Zinc, Copper and Selenium. Materials and Methods: This study enrolled 50 psoriasis patients with 37 males and 13 females, with 10- 80 years age. The patients were randomly selected from the outpatient clinic of Dermatology, Venereology and Leprosy Department, Narayana medical college and hospital. The age, sex matched 50 healthy volunteers included as controls in this study. Levels of serum Copper (Cu), Zinc(Zn), and Selenium(Se) analysed using Atomic absorption Spectrophotometery. Results: In our study, the mean Serum Zinc, Selenium and Copper levels were 61.9680±15.96824, 64.2060±17.44780 and 56.4120±8.51976 respectively, lower than the controls which was stastically significant (P<0.05). Conclusion: In psoriasis, serum Cu, Zn and Se levels were observed to be low, needs to manage therapeutically by oral supplementation. More studies are required to carryout to standardize the diagnostic levels of Cu, Zn and Se and their role in psoriasis pathogenseis. © 2019 Published by Innovative Publication. 1. Introduction Psoriasis, chronic inflammatory and hyper proliferative papilosquamous skin disease, characterized by erythema- tous papules and plaques with silvery white scales cover. It ranges in severity from a few plaques to involvement of almost the entire body surface. 1 The pathogenesis of psoriasis is still poorly understood. It results from the interactions between genetic predisposition and a large spectrum of environmental risk factors, such as diet, alcohol consumption, stress, obesity, smoking. 2 Essential trace elements like copper, Zinc, selenium, manganese, iodine, iron, cobalt, tin, molybdenum, and chromium. 3 There is very limited data available on role of trace elements in etiopathogenesis of psoriasis. In the current study, the role of trace elements in psoriasis was * Corresponding author. E-mail address: drmahaboobvs@gmail.com (V. Mohan Rao). investigated. 4 The environment and skin metabolism may contribute to treatment of psoriasis, by producing oxygen species which causes the oxidative Table 1: Mean serum levels of Zn, Cu and Se in cases and controls. Cases N=50 Control N=50 p value Zinc 61.9680 ±15.96824 78.2280 ± 12.80776 <0.0001 Copper 64.2060 ± 17.44780 114.5800 ± 19.71284 <0.0001 Selenium 56.4120 ± 8.51976 85.6300 ± 11.95779 <0.0001 stress. 5,6 Trace elements influences the immune responses and enzymatic activities, the imbalance in trace elements leads changes in the enzymatic dependant https://doi.org/10.18231/j.ijced.2019.051 2581-4710/© 2019 Published by Innovative Publication. 239