Open Access Journal of Chemistry Volume 3, Issue 3, 2019, PP 22-28 ISSN 2637-5834 Open Access Journal of Chemistry V3 ● 13 ● 2019 22 A Review on a Some Analytical Methods for Determination of Salicylic Acid Amina M. Abass 1* , Jamal M. Rzaij 2 , Huda ghalib Salman 1 , Wisam Kadhum H.Al-Hashemi 1 1 Department of Chemistry, College of Science, Al-Nahrain University, Al-Jaderia, Baghdad-Iraq 2 Department of Physics, College of Science, University of Anbar, Ramadi, Iraq *Corresponding Author: Amina M. Abass, Department of Chemistry, College of Science, Al-Nahrain University, Al-Jaderia, Baghdad-Iraq. Email: aminamohsen75@gmail.com INTRODUCTION Salicylic acid is chemically 2-hydroxy benzoic acid that has antiseptic, antifungal and keratolytic properties. It is used to treat warts, psoriasis, corns and other skin conditions. It works by softening and loosening dry, scaly, or thickened skin so that it falls off or can be removed easily [1,2]. Salicylic acid is white or almost white, crystalline powder or white or colorless, acicular crystals, slightly soluble in water, freely soluble in ethanol, sparingly soluble in methylene chloride, Its molecular formula is C 7 H 8 O 3 and molecular weight is138.1 gm mole -1 . Its melting point is 158-161 0 C., chemical structure shown in Figure 1[3]. Figure1. Chemical structure of Salicylic acid In this literature review, various analytical methods are demonstrated for salicylic acid, some of these techniques are reported and it is given as Table1, Table 2 and Table 3 Table1. Spectro photometric methods for determination salicylic acid Name of Method Results Ref. No UV-Spectral absorption by change in PH Sample :Aspirin in blood λ max used=300, 319 nm Range of acetylsalicylic acid=9.3-10.2 mg/μ.,with SD= ±0.32 Range of salicylic acid=22.2-23.7 mg/μ.,with SD= ±0.77 4 UV-Visible Spectrophotometric Sample :salicylic acid λ max used=300 and 250 nm. Concentration Range=5-50μg/ml %Drug content in marketed formulation=103.85 5 PH-Selective Visible Spectrophotometric Sample :salicylic acidas a chromogenic agent λ max used=520 , 460 nm. 6 ABSTRACT Salicylic acid is being used as a keratolytic agent for treatment of corns or verrucae; it’s being used in many ointments and medicines due to its ability to remove the stratum corneum. Since such products containing salicylic acid are easily obtainable, salicylic acid poisoning (salicylism) cases are relatively many especially for infants not older than 5 years. Its poisoning symptoms were reported to be headache, vertigo, tinnitus, bradyacusia, amblyopia and sweating. There are many analytical techniques that have been reported for simultaneous estimation of salicylic acid and its derivative pharmaceutical dosage form such as : Aspirin, acetylsalicylic acid, salicylamide, sodium salicylate, p-amino salicylic acid and methyl salicylate. Some of those techniques are UV Spectrophotometry, high-performance liquid chromatography (HPLC),liquid chromatography - mass spectrometry (LC-MS), gas chromatography (GC), and ultra-performance liquid chromatography UPLC), In addition of various analytical methods are available for the quantification of pharmaceutical forms, ion-Selective Electrodes one of the most important chemical technique which used for determination of salicylic acid in pure and pharmaceutical formations. Keywords: ISEs, Salicylic acid, Review, Analytical Methods. Spectrophotometry, HPLC