May 2020 · Volume 9 · Issue 5 Page 2187 International Journal of Reproduction, Contraception, Obstetrics and Gynecology Taheri H et al. Int J Reprod Contracept Obstet Gynecol. 2020 May;9(5):2187-2190 www.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789 Case Report Primary breast lymphoma: a case report Hafsa Taheri*, Asma Hmila, Hanane Saadi, Ahmed Mimouni INTRODUCTION Primary breast lymphoma (PBL) is characterized by primary degeneration of the breast lymphoid tissue with or without damage to the lymph nodes in the drainage area. In 1972, Wiseman and Liao defined PBL on the basis of three precise criteria: • Presence of mammary glandular tissue in the middle of the lymphomatous infiltrate or in its direct contact, detected by a good quality sample. • The absence of systemic metastases in the extension assessment. • The absence of a history of extra mammary lymphoma. Primary breast lymphomas represent 1.7% to 4% of extra lymph node lymphomas and less than 1% of non- Hodgkin's lymphomas. 1,2 There are only a hundred cases of PBL reported in the literature. In this article, by reporting the case of a patient with diffuse large B-cell breast lymphoma, we will focus our discussion on PBL, its clinical presentations, histological particularities and management methods. CASE REPORT Our patient is a 33 years-old woman, with no medical history, who had a nodule of the upper medial quadrant of the right breast gradually increasing in volume. The patient underwent a bilateral mammography showing a large multi-lobular nodular image measuring 4.5 cm of the right breast without suspicious microcalcifications or axillar lymphadenopathy. The ultrasound complement showed in projection of the upper medial quadrant of the right breast a large nodular hypo echogenic macro and micro lobulated image of 4.5/2.5 cm hyper vascularized, classified ACR 4, evoking a phyllode tumor (Figure 1). A tumorectomy was performed, in a private hospital, whose anatomopathological result showed a malignant ABSTRACT Primary breast lymphoma is a primary degeneration of the breast lymphoid tissue. Study aim to describe primary breast lymphoma; its clinical presentations, histological particularities and management methods. A 33 years-old patient with no medical history underwent a breast surgery. Its anatomo-pathological study, supplemented by immunohistochemistry, showed a primary breast lymphoma. The extension assessment was negative. The patient underwent chemotherapy with regression of the tumor. Breast lymphomas are rare conditions. Its clinical symptomatology is polymorphic and the imaging aspects are non-specific. It should be evoked in front of any breast tumor in order to avoid heavy breast surgery since the basic treatment is based on chemotherapy. Keywords: Breast, Diagnosis, Lymphoma, Primary, Treatment Department of Obstetrics and Gynecology, Mohammed VI University Hospital, Oujda, Morocco Received: 05 March 2020 Accepted: 30 March 2020 *Correspondence: Dr. Hafsa Taheri, E-mail: drtaheri.hafsa@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20201833