International Journal of Research & Review (www.ijrrjournal.com) 1 Vol.6; Issue: 7; July 2019 International Journal of Research and Review www.ijrrjournal.com E-ISSN: 2349-9788; P-ISSN: 2454-2237 Original Research Article Study of Cellular Morphometry in Colorectal Epithelial Lesions with Clinicopathological Correlation Dr. Koushik Chakraborty 1 , Dr. Sucharita Sarkar 2 , Dr. Asim Kumar Manna 3 , Dr. Saswati Sengupta 4 , Dr. Mousumi Bag 4 1 Consultant Pathologist, Mohan’s Diabetic Clinic, Kolkata, West Bengal 2 Demonstrator, R.G Kar Medical College & Hospital, Kolkata -700004, West Bengal. 3 Professor, Institute of Post Graduate Medical Education and Research, Kolkata-700 020, West Bengal 4 Post Graduate Trainee, Dept of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata-700 020, West Bengal Corresponding Author: Dr. Sucharita Sarkar ABSTRACT Diseases of the colon and rectum v.i.z. different types of colitis, polyps and colorectal carcinoma are representing a wide spectrum of differential diagnosis. This study was expected to classify different colorectal epithelial lesion with the help of various cellular morphometry in different types of lesions. In the study, morphometric parameters including nuclear and cytoplasmic dimensions as well as nucleo/cytoplasm ratio in different colonic and rectal epithelial lesions. Juvenile Polyp v/s Adenomatous Polyp showed significant difference between mean nuclear diameter (p value=0.0013), mean nuclear area (p value=0.0015) and mean nuclear perimeter (p value=0.0013) & nucleo- cytoplasmic ratio (p value=0.00003) Polyp. Adenomatous Polyp v/s Adeno Carcinoma showed the mean cytoplasmic diameters (p value=0.00002) and the nucleo-cytoplasmic ratio (p value=0.00003) did show immensely significant difference and so Adeno Carcinoma v/s Poorly- differentiated Carcinoma (mean nuclear diameter (p value=0.006), mean nuclear area (p value=0.0023) and mean nuclear perimeter (p value=0.006) nucleo-cytoplasmic ratio (p value=0.00180). So, it was concluded that even with the advent and popularity of immunohistochemistry, morphometric study was also found reliable resolving diagnostic dilemmas between benign, premalignant and malignant colorectal epithelial lesions. Keywords: Colorectal carcinoma, Polyp, Morphometry, Nuclear diameter INTRODUCTION Intestinal mucosa is susceptible to many pathological processes like autoimmune and malignant diseases. [1] The intestinal mucosa contains two types of cells: - absorptive cells in luminal side and mucus-secreting Goblet cells predominate in the base of the Crypts. [2, 3] Infective colitis, Microscopic colitis, including the two diseases- collagenous colitis and lymphocytic colitis, Pseudomembranous Colitis, Ischaemic colitis, Colonic polyps, inflammatory polyps. Ulcerative colitis, Colitis cystica profunda and ultimately Carcinoma of colon are identified by well defined histomorpho- logical changes. Now the question is whether colon cancer arises as such, or is it the outcome of repeated genome alterations manifested by well defined histomorphological changes, known as the "Polyp-cancer sequence"?