International Journal of Research & Review (www.ijrrjournal.com) 360 Vol.6; Issue: 12; December 2019 International Journal of Research and Review www.ijrrjournal.com E-ISSN: 2349-9788; P-ISSN: 2454-2237 Review Article Role of Glutathione Peroxidase [GPx] in Peripheral Neuropathy: A Critical Update on Clinical and Experimental Studies Mohammed Zoheb 1 , Zareena Parveen 3 , Arshiya Afreen 3 , Shafia Siddiqui 3 , Tanveer Yousra 3 , Sadiya Mustafavi 3 , Mohd Mohiuddin 4 , Mohd Ishaq 2 1 Assistant Professor Department of Neurology, Deccan College of Medical Sciences, Princess Esra Hospital, Hyderabad. 2 Professor and Head of Department of Salar-e-Millat Sultan Salah Uddin Owaisi Research Centre for Cellular and Molecularmedicine, Princess Esra Hospital, Hyderabad. 3 Department of Pharmacy Practice, Deccan School of Pharmacy, Aghapura, Hyderabad. 4 Department of Pharmacology, Deccan School of Pharmacy, Aghapura, Hyderabad. Corresponding Author: Mohd Ishaq ABSTRACT Glutathione peroxidase, a Selenium containing enzyme, protects the cells by acting as an antioxidant and neutralizing free radicals. The present review highlights the role of Glutathione Peroxidase in Diabetic Peripheral Neuropathy as well as some of the Neurodegenerative disorders like Alzheimer’s Disease and Parkinson’s disease which contributes to increase mortality and effecting quality of life in many individuals throughout the World. However, the role of Glutathione peroxidase is found important even in animals. Various studies showed that Gpx1gene knockout experiment in mice leads to Diabetic Peripheral Neuropathy. The mice found deficient in cellular GPx show no increased sensitivity to Hyperoxia and apart from this deficiency of Gpx1 accelerates the progression of Atherosclerosis in Apolipoproteins E-deficient mice. Keywords: Glutathione peroxidase, Diabetic Peripheral Neuropathy. INTRODUCTION Diabetes Mellitus is a group of chronic multifactorial disorder characterized by hyperglycemia which is associated with increased morbidity and mortality. The complications associated with Diabetes Mellitus are more in macro and micro vascular. DIABETIC PERIPHERAL NEUROPATHY: One of the frequently observed microvascular complication is the Diabetic Peripheral Neuropathy [DPN]. DPN is a condition caused due to progressive elevation of high blood glucose levels which leads to nerve damage. [1] EPIDEMIOLOGY: The incidence of DPN in Diabetic Population was found to be 50%, the world Diabetic population in 2013 was found to be 382 million and it has been estimated that it may rise to 592 million by 2035. [2] Therefore, understanding pathogenesis, progression and management of DPN assumes great significance. CHARACTERISTIC FEATURES OF DPN: DPN is characterized by abnormal nerve conduction and thermal perception, another important feature is Axonal atrophy, demyelination blunted regenerated potential and loss of nerve fibers. [3] It is intricated with inflammation and degeneration of