Investgaton of Some Haematological Parameters in Pregnant Women with Gestatonal Diabetes at Federal Medical Center, Owerri, Imo State, Nigeria Okorie Hope 1,2 Obeagu Emmanuel Ifeanyi 1,3* and Anaebo Queen Braxton N 4 1 Department of Medical laboratory Science, Imo State University, Owerri, Nigeria 2 Department of Medical Laboratory Science, Rivers State University, Port Harcourt, Rivers State, Nigeria 3 Medical Laboratory Science, University Health Services, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria 4 Department of Accident and Emergency, Lagos University Teaching Hospital, Lagos, Nigeria Corresponding author: Obeagu Emmanuel Ifeanyi, Department of Medical laboratory Science, Imo State University, Owerri, Nigeria, Tel: + 2348037369912; E-mail: emmanuelobeagu@yahoo.com Received: April 17, 2019; Accepted: April 30, 2019; Published: May 08, 2019 Citaton: Hope O, Ifeanyi OE, Braxton AQ (2019) Investgaton of some Haematological Parameters in Pregnant Women with Gestatonal Diabetes at Federal Medical Center, Owerri, Imo State, Nigeria. Ann Clin Lab Res. Vol 7. No.2:305. Abstract This study was conducted to investgate some haematological parameters in pregnant women with Gestatonal Diabetes at FMC, Owerri, Imo state. Seventy (70) pregnant women were recruited in the study of which ffy (50) are sufering from gestatonal diabetes, while twenty (20) are normal pregnant women serving as the control. Haematoloical parameters were determined using standard haematological procedures, data obtained from the study were analysed using the SSPS package. Haemoglobin concentraton was signifcantly (p<0.05) higher in gestatonal diabetc women (11.49 ± 1.01 g/dl) when compared with the control subjects (normal healthy pregnant women) (10.7 ± + 0.75 g/dl)). PCV in gestatonal diabetc women (33.84 ± 3.26%) was signifcantly (p<0.05) higher when compared to controls (32.06 + 2.15%). Platelet count was signifcantly (p<0.05) higher in gestatonal diabetc women (512.52 ± 106.76l0 9 /L) when compared to the control subjects (197.60 ± 77.62 l0 9 /L). The mean value of TWBC was signifcantly higher (p<0.05) in gestatonal diabetc women (8.07 ± 2.01l0 9 /L) when compared with the control subject (5.38 ± 1.89 l0 9 /L). Neutrophil count was signifcantly (p<0.05) higher in gestatonal diabetc women (53.04 ± 9.99%) when compared to controls (43.60 ± 6.24%). There was no statstcally signifcant diference (p>0.05) in the mean value of eosinophil count in gestatonal diabetc women (0.28 + 0.54%) when compared with the control subjects (0.20 + 0.41%). Basophils were not seen in gestatonal diabetc women and the control subjects. Lymphocyte count was signifcantly (p<0.05) reduced in gestatonal diabetc women (45.78 ± 09.92%) when compared with the control subject (56.70 + 5.32%). There was no statstcally signifcant diference (p<0.05) in the mean value of lymphocyte count in gestatonal diabetc women (0.10 + 0.00%) when compared with the control subjects (0.30 + 0.00%). In conclusion, gestatonal diabetes has a signifcant efect on some haematological parameters. Keywords: Haematological parameters; Pregnant women; Gestatonal diabetes Introducton Diabetes is a disease of metabolism clinically expressed by chronic hyperglycemia and blood lipid and protein disorders that have been extensively reported as linked to several complicatons that cause morbidity and mortality [1]. Diabetes and uncontrolled hyperglycemia are known to play a signifcant role inthe development of cardiovascular disease (CVD) since Framingham study [2]. Gestatonal diabetes is a conditon in which a woman without diabetes develops high blood sugar levels during pregnancy [3]. Gestatonal diabetes generally results in few symptoms; however, it does increase the risk of pre-eclampsia, depression, and requiring a Caesarean secton [3]. Babies born to mothers with poorly treated gestatonal diabetes are at increased risk of being too large, having low blood sugar afer birth, and jaundice. If untreated, it can also result in a stllbirth [3]. Long term, children are at higher risk of being overweight and developing type 2 diabetes. Additonally, besides the diabetes and classical risk factors, the presences of microvascular complicatons are also predictor of coronary heart events [4]. In additon to this, statstcs show a double risk of GDM in smokers [5]. Polycystc ovarian syndrome is also a risk factor, although relevant evidence remains controversial. Some studies have looked at more controversial potental risk factors, such as short stature [6]. About 40-60% of women with GDM have no demonstrable risk factor; for this reason many advocate to screen all women [6]. Typically, women with GDM exhibit no symptoms (another reason for universal screening), but some women may demonstrate increased thirst, increased urinaton, fatgue, nausea and vomitng, bladder infecton, yeast infectons and blurred vision. In additon to atheroma formaton, the combinaton of hypercoagulability, impaired fbrinolysis and impaired vasodilaton likely further increases the risk of vascular occlusion and cardiovascular events in diabetes [7]. In recent years, there has been renewed interest in hematological parameters such as white blood count (WBC), Research Article iMedPub Journals http://www.imedpub.com/ DOI: 10.21767/2386-5180.100305 Annals of Clinical and Laboratory Research ISSN 2386-5180 Vol.7 No.2:305 2019 © Under License of Creative Commons Attribution 3.0 License | This article is available from: http://www.aclr.com.es/ 1