Asian Journal of Medical Radiological Research ¦Volume 7 ¦ Issue 2 ¦ July- December 2019 188 Abstract Role of Placenta Location and Uterine Artery Doppler Assessment at 18 To 24 Weeks as Predictors of Pre-Eclampsia Navkiran Kaur 1 , Piyush Singh 2 , Parneet Kaur 3 1 Professor and Head Deptt. of Radiodiagnosis, Govt. Medical College, Rajindra Hospital, Patiala, 2 Resident, Deptt. of Radiodiagnosis, Govt. Medical College, Rajindra Hospital, Patiala, 3 Professor, Dept. of Obst & Gynae, Govt. Medical College, Rajindra Hospital, Patiala. Background: Preeclampsia, a pregnancy disorder, is defined as a systemic syndrome characterized by new-onset of hypertension and proteinuria after 20 weeks of gestational age in pregnant women, which resolves before the end of 6th week postpartum. Hence; under the light of above mentioned data, we planned the present study to establish the role of placenta location and uterine artery doppler assessment at 18 to 24 weeks as predictors of pre-eclampsia. Subjects and Methods: First 100 patients were scanned at 18-24 weeks and were followed up till delivery. The location of the placenta and uterine artery Doppler was determined by ultrasound using Phillips HD11 XE ultrasound machine with a 3.5-MHz curvilinear transducer at 18-24 weeks in all the cases at the time of scan. The end point of the study was the development of preeclampsia. The study group included 100 patients reporting to ultrasound section. Grey scale ultrasound and colour doppler was performed. Any co-relation of radiological findings with clinical and surgical findings were documented and analysed. Results: Significant results were obtained while assessing distribution of patients in relation to lateral placenta location, Doppler study and occurrence of pre-eclampsia. 87 percent of the patients had central located placenta while in the remaining 13 percent of the patients had lateral located placenta. While assessing the 100 patients, we observed that Pre-Eclampsia was found to be present in 12 percent of the patient. Conclusion: By identifying the high risk patients & anticipating preeclampsia patients can be monitored more closely to reduce the morbidity and improve the outcome of pregnancy. Keywords: Doppler, Preeclampsia Corresponding Author: Dr. Piyush Singh, Deptt. of Radiodiagnosis, Govt. Medical College, Rajindra Hospital, Patiala Received: January 2020 Accepted: January2020 Introduction In normal pregnancy, placental trophoblast cells invade the inner third of the myometrium and migrate the entire length of the maternal spiral arteries what optimizes delivery of oxygen and nutrients to the fetus. [1] Preeclampsia, a pregnancy disorder, is defined as a systemic syndrome characterized by new-onset of hypertension (blood pressure – systolic > 140 mm Hg, diastolic > 90 mm Hg on two occasions at least 4 h apart, or in severe cases systolic blood pressure >160 mm Hg and diastolic blood pressure > 110 mm Hg) and proteinuria (protein [mg]/ creatinine [mg] ratio of > 0.3 or protein > 5 g in a 24 h urine sample, or > 3 g in two samples taken 6 h apart from a patient on bed rest) after 20 weeks of gestational age in pregnant women, which resolves before the end of 6th week postpartum. In the absence of proteinuria, preeclampsia presents with hypertension associated with any features of end organ damage. Eclampsia is characterized by onset of seizures in pregnant women with preeclampsia. [2- 5] Abnormal uterine artery Doppler studies in both the first and second trimesters have been shown to be associated with subsequent perinatal complications. For women with abnormal testing in the first trimester, the likelihood ratio (LR) for the development of preeclampsia is approximately 5, while those with normal Doppler flow studies have an LR of 0.5. Similarly, an abnormal test carries an LR of 2 for fetal growth restriction, with an LR of 0.9 after a normal test result. Though this relationship persists with testing in the second trimester, the sensitivity may be lower. [6, 7] Hence; under the light of above mentioned data, we planned the present study to establish the role of role of placenta location and uterine artery doppler assessment at 18 to 24 weeks as predictors of pre-eclampsia. subjects and Methods The prospective observational study was conducted at Rajindra Hospital, Government Medical College, Patiala, Punjab (Department of radiodiagnosis) for a period of 24 months from November 2017 to November 2019. First 100 patients were scanned at 18-24 weeks and were followed up till delivery. The location of the placenta and uterine artery Doppler was determined by ultrasound using Phillips HD11 XE ultrasound machine using a 3.5-MHz curvilinear transducer at 18-24 weeks in all the cases at the time of ISSN (0): 2347-338X; ISSN (P): 2347-3371 Original Article