IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 19, Issue 6 Ser.13 (June. 2020), PP 56-57 www.iosrjournals.org DOI: 10.9790/0853-1906135657 www.iosrjournal.org 56 | Page Differential Blood Count In Patients with Novel Coronavirus Infection: A Retrospective Study Dr.Kanchan Kumari 1 , Dr. Pramod Kumar 2 , Dr.Sudipto Roy 3 , Dr. Vinay Prabhat 4 1 (Senior Resident,RIMS, Ranchi) 2 (Senior Resident,RIMS, Ranchi) 3 (In-charge,Labmedicine,RIMS,Ranchi) 4 (Assistant Professor,RIMS,Ranchi) Abstract: Study Design: Retrospective study. Purpose: The objective of our study to analyse differential blood count (DC) and reveal infectious characteristics of novel coronavirus COVID 19. Background: Afterinitial epidemic outbreak in wuhan (china), novel coronavirus COVID 19 became pandemic and reached more than 95% of the countries of the world. Since it is a new virus and very few information had been known about it; our aim to analyse differential blood count (DC) and reveal infectious characteristics of novel coronavirus COVID 19. Methods: We performed a retrospective study on 60 COVID-19 cases with laboratoryconfirmed cases in COVID centre of Rajendra institute of medical sciences,Ranchi, Jharkhand, India during march 2020 to may 2020. Results: Out of 60 patients, 65% were male and female patients account for 35%. The aged in 11~20, 21~35, over 50 years were accounts for 20%, 38.3%,15%, respectively; while The aged below 10 years accounts for only 5% of overall patients. Fever ( 83.3% ) and Cough ( 68.3%) were common clinical symptoms. Total leukocyte count were roughly within normal limit except in patients with severe symptoms. Lymphocytes count were in lower range in almost all patients but lymphocytopenia was there in 41.6% of cases and severity of lymphopenia was associated with severity of symptoms. Conclusions: Our data provide information that lymphocytes counts were in lower range in overall diagnosed COVID-19 patients and severe Lymphopenia may be a risk factor with poor prognosis.Total leukocyte count were within normal limit except in severe cases that may be due to accompanying bacterial infection Key words: novel coronavirus; Differential count; COVID-19; risk factor; Lymphocyte count --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 08-06-2020 Date of Acceptance: 25-06-2020 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction After outbreak in wuhan (china) in December 2019, infection of novel corona virus (COVID 19) became pandemic and involved more than 90% of counties of world 3 . It is a beta coronavirus that possibly originated from wild animals that genome is highly homologous to bats 1 . Until 13 th June 2020, It has affected 78 lakh population worldwide and 4.3 lakh patients had lost their life due to it. The World Health Organization (WHO) has declared it to be a public health emergency of international concern. India is the 2 nd most populous country and first according to population density. As human to human transmission is the main way and henceforth it is very difficult task to prevent, control and manage COVID 19 patients in developing country like India 2,4 . Until 13 th June 2020, infection had reached up to 3.18 lakh with death of about 9000 people. Despite the rapid spread over the world, the clinical features and laboratory inspection of COVID-19 keep largely unclear. Coronavirus (COVID 19) can cause myriad of symptoms ranging from asymptomatic to severe life disabling pneumonia. Clinical characteristics of severe COVID 19 pneumonia resemble to that of Severe acute respiratory syndrome (SARS) and acute respiratory distress syndrome (ARDS) 5 .The main clinical features of COVID-19 patients are fever, cough and sore throat and in some cases anosmia occasionally. As COVID 19 is new virus and hence pathophysiologic mechanism, monitoring parameters and management are largely unknown. Our aim is to analyse differential blood count (DC) picture in patients with COVID 19 infection diagnosed by RTPCR.