IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 19, Issue 6 Ser.12 (June. 2020), PP 09-14 www.iosrjournals.org DOI: 10.9790/0853-1906120914 www.iosrjournal.org 9 | Page A Study on Thyroid Profile in Females with Depression in Rayalaseema Region 1. Dr. M. Siva Kumar; 2. Dr. K. Madhavi; 3. Dr. Jayapriya T * ; 4. Dr. Vinayaka Naik. I 1. Research Medical Scientist (MRU-VDRL), S.V Medical College, Tirupati. 2. Professor & Head, Dept. of Biochemistry, S.V Medical College, Tirupati. 3. Assistant Professor, Dept. of Psychiatry, Bharath Medical College, Chennai. 4. Assistant Professor, Sri Padmavathi Medical College For Women, Tirupati. Corresponding Author: Dr. Jayapriya T * Abstract: AIM: Aim of the study is to see for the thyroid function (T3, T4, TSH), Lipid patterns and glycemic control in females newly diagnosed with depression attending Psychiatry Department, (I.P&O.P) Sri Venkateswara Medical College, Tirupati and compare them to the levels in normal females without depression. OBJECTIVES: To estimate serum levels of TSH, T3, T4 (Thyroid profile) in females newly diagnosed with depression and to estimate serum levels of TSH, T3, T4 (Thyroid profile), in age matched females without depression. To Compare the serum levels of TSH, T3, T4 (Thyroid profile) in females newly diagnosed with depression to that of normal females. MATERIAL AND METHODS: study subjects were selected from Psychiatry department, SVRRGH and study were conducted in department of Biochemistry. Two groups of subjects 50 each as group 1(cases) and group 2 (controls) were selected based on inclusion and exclusion criteria. Results of cases are compared with that of controls and are tabulated. Conclusion: study may be useful in understanding the risk factors of depression and this forms an area for the research work which if detected early can be managed accordingly and may prevent the morbidity and mortality due mood disorders like depression. --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 06-06-2020 Date of Acceptance: 22-06-2020 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Depression is known to mankind since many years. The World Health Organization has ranked depression fourth in a list most urgent health issues worldwide 1 . It is projected that depression will be second largest killer disease after heart disease by 2020 and second major leading cause of Disability Adjusted Life Years(DALYS)(1). Etiology of depression, among mood disorders is although most frequently studied, yet it is far away from ideally understood. Increased activity in the Hypothalamo-pituitary-Adrenal (HPA) axis leads to depression and it is viewed as the “most vulnerable finding in biological psychiatry”. Major Depressive Disorder (MDD) has been associated with significant changes in the Hypothalamic-pituitary-Thyroid axis 2 . Research findings have extended the relationship between thyroid and mood disorders. It has long been recognized that hypothyroidism can cause depressive symptoms and almost always in severe cases 3,4 . Patients with subclinical hypothyroidism have been noted to have a higher than normal life time prevalence of depression 5-7 . Depression leads to state of constant stress and which usually leads to activation of HPA axis this in turn may lead to metabolic disturbances 8 . The correlation between the serum lipids and depression is debatable. Many attempts have been done to find out the correlation of hypercholesterolemia with depression. While some reports say that low serum cholesterol is associated with depression, other demonstrate higher depressive scores and TSH values in patients with high cholesterol levels 9-11 . The conventional wisdom is that hypothyroidism may be reversible cause of depression. Depression is much more common in females than males thus females are a focus of special care. II. Material And Methods A cross sectional study done after approval from ethical and dissertation committee in Sri Venkateswara Medical College, Tirupati. Informed written consent is taken from all patients participating in the study. Study duration: From the date of scientific committee and ethical committee approval study was conducted for one year. Source of data: Study subjects were selected from Psychiatry department, SVRRGH and