IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 19, Issue 6 Ser.17 (June. 2020), PP 10-14 www.iosrjournals.org DOI: 10.9790/0853-1906171014 www.iosrjournal.org 10 | Page A Clinical Study of Malignancy in Solitary Thyroid Nodule Dr.K. Manohar;Dr G Prasanna Lakshmi Bai;Dr. G.V. Prakash;Dr. G.V. Ramanaiah;Dr Gsr Harish ABSTRACT BACKGROUND: Solitary nodule of thyroid has increased in incidence in the resent day as compared to two decades before. Because of Possibility of malignancy all nodules have to be removed. MATERIALS AND METHODS: Prospective study of 100 patients who presented to the outpatient department and surgical wards of S.V.R.R.G.G.H, Tirupathi. During the period of September 2018 to August 2019 with a clinically detected STN was included in the study group. Preoperative Ultrasonography (USG) and fine-needle aspiration cytology were planned in all these patients. Hemi thyroidectomy and Total thyroidectomy with and without neck dissection were performed wherever appropriate. RESULTS: Commonest presentation of solitary thyroid nodule was asymptomatic.The peak incidence of solitary nodule was observed in 3-5 th decade , constituting 60% of the cases studied. Females predominated in number over males in occurrence of solitary thyroid nodule in ratio of 1;4.88.The common causes of solitary thyroid nodule was Nodular goiter(67%),follicular adenoma(19%)(excluding MNG).97% of cases presented with Euthyroid state. incidence of malignancy in solitary thyroid nodule was 12%.Male to Female ratio in case of malignant nodule was 1:8.5.but incidence of carcinoma in males presenting as solitary nodule was higher(41%) compared to that of females(9%).The most common cause of malignancy was papillary carcinoma(75%) followed by follicular carcinoma(25%). CONCLUSION: Solitary thyroid nodule is more common in females. Solitary thyroid nodule is more common in the age group of 20-50 years. Most of patients with STN present with swelling alone. Most of patients with STN are euthyroid state. Only few present with toxicity and hypothyroidism. Incidence of malignancy in male patients presenting with STN is more compared to females. Common cause of STN is Adenoma (excluding MNG). Papillary carcinoma is the most common malignancy of thyroid, followed by follicular carcinoma. KEY WORDS: Solitary thyroid nodule, Papillary carcinoma, Incidence of carcinoma, Adenoma, MNG. --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 10-06-2020 Date of Acceptance: 27-06-2020 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Thyroid nodules are very common. The incidence of nodules in general population is 4-7%. Solitary nodules of thyroid are four times more common in women than in men. Overall incidence of malignancy in solitary thyroid nodule ranges from 8-10% solitary nodule is defined as a palpable single clinically detected nodule in the thyroid is discovered by either the patient or the clinician. Because of possibility of malignancy, some clinicians especially those in surgical Specialities recommend that all nodules have to be removed. On the other hand endocrinologist recommends FNAC performed as initial step of evaluation in order to avoid unnecessary surgery. II. Materials And Methods The present study on “Clinical Study of malignant in Solitary Thyroid Nodule” has been conducted b y utilizing 100 cases admitted and managed in the Department of general surgery SVRRGGH,Tirupathi. Study Design: Prospective study. Study Location: SVRR Government General Hospital,Tirupathi. Sample size: 100 cases. Study Duration: September 2018 to August 2019. Subjectives and selective methods: Total 100 cases admitted and managed in the Department of General Surgery,S.V.R.R.Govt.General Hospital,Tirupathi. Inclution criteria: Patients above 18 years of age clinically presenting with Solitary thyroid nodule.