International Journal of Research & Review (www.gkpublication.in) 6 Vol.3; Issue: 6; June 2016 International Journal of Research and Review www.ijrrjournal.com E-ISSN: 2349-9788; P-ISSN: 2454-2237 Review Article A Review on Smart Delivery of Drugs Arpita Samanta 1 , Bidyut Bandyopadhyay 1 , Nirmalendu Das 2 1 Department of Biotechnology, Oriental Institute of Science and Technology (Vidyasagar University), Dewandighi, Burdwan-02, India. 2 Drug Development Diagnostics and Biotechnology, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India. Corresponding Author: Nirmalendu Das Received: 31/05/2016 Revised: 10/06/2016 Accepted: 16/06/2016 ABSTRACT Drug delivery mention to approaches, formulations, technologies, and systems for deporting pharmaceuticals in the body by maintaining safety concern with therapeutic achievements. Drug delivery necessitates targeting site in the body, and makes the clear way for systemic pharmacokinetics. It is commonly troubled with the quantity and persistence time of drug in the system. Drug delivery is frequently accomplished through chemical formulation of drug alone, but also involves in drug vehicle combination products. Drug delivery is an idea where much emphasis should be given to dosage and route of delivery. It is important to explore the viability of the systems by scaling up from the laboratory to the production scale. Key words: Drug delivery, sustained release, drug absorption, skin, brain, cancer. INTRODUCTION Drug delivery is a concept of safely transporting a pharmaceutical component in body to get its maximum therapeutic benefits. Quantity and the duration of drug presence both are managed through drug delivery system. The system uses different devices to achieve systemic pharmacokinetics to provide best therapeutic goal with minimum side effects. The main target of drug delivery system is to work with minimum drug loss and maximum exposer to target area of body. So drug must be stable in terms of physical and chemical environment and contamination free for safe delivery. The achievement of drug delivery system lies in reducing drug interaction and side effects along with target specific application. Optimization needed to finally formulate a drug to be delivered through smart approach (Figure 1). Figure 1: Optimization needed to formulate medicine from drug Drug Delivery: Drug delivery emphasises its efficacy and safety with the following:  Release  Absorption  Distribution  Elimination Drug release is perused through dispersal, degradation, bulging. The