International Journal of Research and Review Vol.7; Issue: 6; June 2020 Website: www.ijrrjournal.com Case Report E-ISSN: 2349-9788; P-ISSN: 2454-2237 International Journal of Research and Review (ijrrjournal.com) 356 Vol.7; Issue: 6; June 2020 Minor Salivary Gland Pleomorphic Adenoma: An Inconceivable Diagnosis in a 62 Year Old Female Sireesha K 1 , Anuradha A 2 , Srinivas GV 2 , Bagalad BS 3 , Puneeth HK 3 , Kiresur MDA 3 1 Post Graduate Student, 2 Professor, 3 Assistant Professor, Department of Oral Pathology and Microbiology, St. Joseph Dental College, Duggirala, Eluru, West Godavari (Dt), Andhra Pradesh India. Pin: 534003 Corresponding Author: Sireesha K ABSTRACT Pleomorphic adenoma is the most frequently encountered benign tumor of salivary glands originating from the myoepithelial cells and intercalated duct cells with 90% of cases occurring in major salivary gland and 10% in minor salivary glands. This case report describes a rare and unusual lesion in a 62- year-old female, which was diagnosed as pleomorphic adenoma of the minor salivary glands in the upper lip. The tumor was a circumscribed, submucosal, non-tender nodule, measuring about 1 x 1.5 cm in diameter. Complete excision was performed and the histopathological analysis showed both epithelial and mesenchymal components, arranged in the form of tubules, cords, ducts and focal solid areas. There is no evidence of recurrence. Keywords: Minor salivary glands, Pleomorphic adenoma, Upper lip. INTRODUCTION The pleomorphic adenoma is the most common tumor of the salivary gland, which accounts for 60-65% of all salivary gland tumors. [1] The tumor occurs at any age but most commonly between the fourth and sixth decade of life with female predilection. Approximately 85% of all PA are located in the parotid glands, 10% in the minor salivary glands, and 5% in the submandibular glands. [2] Intraorally palate (60%) is the most common site followed by upper lip (20% cases), buccal mucosa, floor of mouth, tongue, tonsil, pharynx, retromolar area and nasal cavity. [3] The lesion which histologically constitutes admixture of tumors, bone, cartilage, myxoid areas amidst an epithelial component in the form of ducts, sheets and strands, usually presents as an asymptomatic, slow growing, firm mass of size ranging from 1.0 to 1.5cm. We report a case of dome shaped swelling in the upper lip of a middle aged female patient which was clinically mimicking a lipoma, but histopathologically diagnosed as pleomorphic adenoma. CASE REPORT A 62-year-old female visited the outpatient department of St. Joseph Dental College with a chief complaint of a small asymptomatic, slow growing swelling in the right side region of upper lip present since one year [Figure 1]. Extra-oral examination revealed a soft, non-tender, oval swelling measuring 1.0 × 1.5 cm in dimension which was freely movable underneath the superficial skin, located in the right side region of upper lip. The skin above the swelling appeared normal. The head, neck, ear, nose, throat and eye examination revealed no abnormality and no cervical lymphadeno- pathy. On intra-oral examination an obvious dome shaped submucosal swelling with intact overlying mucosa in the upper