862| International Journal of Pharmaceutical Research | Jul - Sep 2020 | Vol 12 | Issue 3 Research Article Development, Optimization and Evaluation of Liquisolid Compact Tablet of Aripiprazole by using Factorial Design DR. BHUPENDRA PRAJAPATI 1 , MS. SHRUTI RAO 2 *, MR. TULARAM BAROT 3 1 Associate Professor, Department of Pharmaceutics, Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat, India. 2 Research Scholar, Ganpat University, Assistant Professor, ROFEL, Shri G.M. Bilakhia College of Pharmacy, Vapi 3 Assistant Professor, ROFEL, Shri G.M. Bilakhia College of Pharmacy, Vapi *Corresponding Author Email ID: stb2528@gmail.com Received: 24.01.20, Revised: 09.02.20, Accepted: 21.03.20 ABSTRACT Liquisolid compact technique was selected to improve the dissolution profile of Aripiprazole. Aripiprazole is used for bipolar disorder, which requires quick action. Formulation was prepared by using Cremophor RH 40 as a non-volatile solvent. Carrier material was selected Neusilin US2 and Coating material was selected was Aerosil 200. Optimization of formulation was performed by applying 3 2 full factorial design. Further, the optimized batch was evaluated. Response surface graph was studied to check the effect of independent variables on dependent variables. The selected independent variables are Drug concentration in liquid medication (X1) and carrier: coating ratio (R) (X2) and dependent variable are cumulative % drug release at 15 min (Y1) and angle of repose (Y2). The optimized liquid medication was converted into solid power form by using adsorbent material. Further it was converted to tablet form and then was evaluated for different parameters. Keywords: Liquisolid compact tablet, factorial design, In vitro dissolution study INTRODUCTION Aripiprazole is an atypical antipsychotic medicament which is used to treat bipolar disorder. The drug acts due to combination of antagonism at D2 receptors and 5HT2A receptors in the mesolimbic pathway and in the frontal cortex respectively. [1] Bipolar disorder is one of the most debilitating, severe, chronic of all medical illness. Drug has also activity against schizophrenia [2]. In this approach drug is dissolved in non-volatile liquid solvent. The coating material and carrier material was added to convert the liquid in solid powder form. Liquisolid compact tablets were prepared by mixing other required excipients. Liquisolid compact shows immediate release profile because the drug is completely get dissolved in liquid. [3] MATERIALS AND METHODS Materials Aripiprazole was gifted from Alembic Pharmaceuticals Ltd. (Vadodara, Gujarat). Polyethylene glycol (PEG) 400, PEG 200, Propylene glycol were procured from Astron chemicals (India). Cremophor RH 40 was gifted from BASF, (Germany). NeusilinUFL2 and Neusilin US2, were procured from A.B. Enterprises (Mumbai). Aerosil 200 and Avicel PH102 from Signet chemical (Mumbai). Crospovidone and Magnesium stearate were procured from Loba chemie Pvt Ltd, (Mumbai). Methods Solubility in non-volatile solvent The solubility study was performed in non-volatile solvents like Propylene glycol, PEG 400, PEG 200, Cremophor RH 40. Saturated solutions were prepared and shake it for 48 hours at 25°C by using shaker. Then it was centrifuged at 15,000 rpm for 30 min. Further the supernant was diluted with ethanol and analyzed in UV spectrophotometer. (Shimadzu UV-1800, Japan) at 248 nm. [4] Selection of carrier and coating material Powder mixtures were prepared with use of carrier and coating material. Each mixture was measured for angle of side by in house lab method. Angle of slide (Ө) was measured in that the mixture slides and the angle formed between the plate and the horizontal surface at which powder mixture slides. The graph was plotted of flowable liquid load factors (Lf) against reciprocal carrier: coating ratios (1/R). From that linear plot, Y-intercept gives (Ф value) the liquid retention potential of the carrier material and a slope gives