NOVATEUR PUBLICATIONS JournalNX- A Multidisciplinary Peer Reviewed Journal ISSN No: 2581 - 4230 VOLUME 6, ISSUE 6, June -2020 58 | Page SOME BIOCHEMICAL INDICATORS OF BLOOD IN PROSPEROUS COWS IN PURE PODODERMATITIS BAKHTIYOR ZOKIROVICH MUKHTAROV, Independent researcher, Samarkand Institute of Veterinary Medicine NASRIDDIN BABAKULOVICH DILMURODOV Professor, Supervisor Doctor of Veterinary Sciences, Samarkand Institute of Veterinary Medicine ABSTRACT: Changes in some biochemical parameters in the blood of productive cows with purulent pododermatitis were studied, and the dynamics of their specific changes when using conventional and non- conventional therapies were determined. The levels of α- and--globulins in the blood of sick cows were low in both experimental groups on the first day of treatment and increased as a result of treatment, which was more rapid in non-conventionally treated cows than in conventionally treated cows. KEYWORDS: Purulent pododermatitis, productive cows, biochemical index, blood, total protein, albumin, alpha-globulin, beta- globulin, gamma-globulin, conventional method, non-conventional method, absolute index, relative index. INTRODUCTION: Purulent pod dermatitis, a common disease among high-yielding cattle, causes great economic damage to farms, especially leading to a sharp decline in milk production from animals. In recent years, due to the conditions of storage of high-yielding cows imported to the country at the expense of large sums from abroad, as well as shortcomings in feeding and other factors, leading to the early exclusion of cows with hoof and joint diseases. The development and implementation of science-based measures aimed at the early detection of diseases and reducing the duration of their treatment are of great practical importance. Hypocalcemia, hypophosphatemia, copper, zinc, reserve alkalinity, calcitonin deficiency, [2]. Germivit, Vitadaptin, and Guvitin-S have been used as dietary supplements in cows during pregnancy, the effects of these biologically active substances on the metabolism have been studied, and the authors have shown that the combined use of biologically active drugs has a positive effect on cow's blood biochemical parameters and regulates metabolic processes. When the blood of cows with hoof ulcers was analyzed, it was found that the number of erythrocytes, hemoglobin, total protein, gamma globulin decreased, and the number of leukocytes increased compared to healthy animals. As a result of complex treatment of purulent- necrotic ulcers of cows' hooves, a decrease in the number of leukocytes in the blood, an increase in erythrocyte count and hemoglobin, as well as an increase in total serum protein and gamma globulin concentrations compared with local treatment [4]. The author called for experimental skin-muscle injury in laboratory animals when 50 and 100% chistotel juice was applied to them, Staph. Aures, Proteus Vulgaris, Escherichia coli, Str. It was noted to be effective against epidermidis microorganisms, and a 10% ointment of chistotel ensured that the skin-muscle injury healed 3 days earlier than in the control group. Based on the results of