ABSTRACT The corona virus disease 2019 (COVID-19) is ongoing pandemic caused by SARS-CoV2. It was first identified in Wuhan, China in Dec 31, 2020. As of June 8, 2020, 69, 31,000 confirmed cases, 4, 00,857 confirmed death around 216 countries areas or territories with cases have been reported by WHO. The clinical trial of COVID-19 is going on Hydroxychloroquine, Azithromycin are given alone and combination and a new antiviral agent Ramdesivir help to some infection. However there is still no available vaccine and potential treatment for this corona virus. These COVID-19 pathogenesis pathways are still unknown. In this literature review we discussed about CoV, SARS-MERS CoV, COVID-19, Clinical manifestation, illness and risk factor, treatment, preventive measures, control the transmission. KEYWORDS Corona virus, SARS-MERS CoV, COVID-19, AYUSH Guideline, and Ayurvedic and Siddha formulation. Ramasamy M. et al. / Asian Journal of Research in Pharmaceutical Sciences and Biotechnology. 8(2), 2020, 72-83. Review Article ISSN: 2349 – 7114 REVIEW ON COVID-19 Anguraj Moulishankar 1 , M. Ramasamy* 2 , S. Ravichandran 2 , K. Gopalasatheeskumar 3 1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai, Tamil Nadu, India. 2* Department of Pharmacology, P.S.V College of Pharmaceutical Science and Research, Krishnagiri, Tamil Nadu, India. 3 Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India. INTRODUCTION The Corona viruses are severe pathogen of human and animal. This novel corona virus was first identified as cluster of pneumonia cases in Wuhan city, Hubei Province, China in Dec, 2019 1 . It easily spread throughout the China, followed spread to the other countries throughout the world due to highly contagious nature. The severe acute respiratory syndrome (SARS) corona virus, Middle East respiratory syndrome (MERS) corona virus and COVID-19 are separately discussed. Corona viridae Available online: www.uptodateresearchpublication.com April – June 72 Asian Journal of Research in Pharmaceutical Sciences and Biotechnology Journal home page: www.ajrpsb.com https://doi.org/10.36673/AJRPSB.2020.v08.i02.A10 Author for Correspondence: Ramasamy M, Department of Pharmacology, P.S.V College of Pharmaceutical Science and Research, Krishnagiri, Tamil Nadu, India. Email: mramoo@gmail.com