International Journal of Electrical and Computer Engineering (IJECE) Vol. 10, No. 1, February 2020, pp. 757~766 ISSN: 2088-8708, DOI: 10.11591/ijece.v10i1.pp757-766  757 Journal homepage: http://ijece.iaescore.com/index.php/IJECE Design and implementation a prototype system for fusion image by using SWT-PCA algorithm with FPGA technique Muthna Jasim Fadhil 1 , Rashid Ali Fayadh 2 , Mousa K. Wali 3 1 Department of Electrical Power Engineering, Electrical Engineering Technical College, Middle Technical University (MTU), Iraq 2,3 Department of Medical Instrumentation Engineering Techniques, Electrical Engineering Technical College, Middle Technical University (MTU), Iraq Article Info ABSTRACT Article history: Received Jan 16, 2019 Revised Sep 17, 2019 Accepted Sep 27, 2019 The technology of fusion image is dominance strongly over domain research for recent years, the techniques of fusion have various applications in real time used and proposed such as purpose of military and remote sensing etc., the fusion image is very efficient in processing of digital image. Single image produced from two images or more information of relevant combining process results from multi sensor fusion image. FPGA is the best implementation types of most technology enabling wide spread.This device works with modern versions for different critical characteristics same huge number of elements logic in order to permit complex algorithm implemented. In this paper,filters are designed and implemented in FPGA utilized for disease specified detection from images CT/MRI scanned where the samples are taken for human's brain with various medical images and the processing of fusion employed by using technique Stationary Wavelet Transform and Principal Component Analysis (SWT-PCA). Accuracy image output increases when implemented this technique and that was done by sampling down eliminating where effects blurring and artifacts doesn't influenced. The algorithm of SWT-PCA parameters quality measurements like NCC, MSE, PSNR, coefficients and Eigen values.The advantages significant of this system that provide real time, time rapid to market and portability beside the change parametric continuing in the DWT transform. The designed and simulation of module proposed system has been done by using MATLAB simulink and blocks generator system, Xilinx synthesized with synthesis tool (XST) and implemented in XilinxSpartan 6-SP605 device. Keywords: FPGA Xilinx system generator Fusion image MATLAB SWT-PCA algorithm VHDL Copyright © 2020 Institute of Advanced Engineering and Science. All rights reserved. Corresponding Author: Muthna Jasim Fadhil, Department of Electrical Power Engineering, Electrical Engineering Technical College, Middle Technical University (MTU), Baghdad, Iraq. Email: mothana.jasim@eetc.mtu.edu.iq 1. INTRODUCTION Several domains ways of acquired information extracting are refered to fusion term where fusion image integrating method of information relevant by images set.Fused image resultant is treated as a single image which is suitable and high informative for processing or perception visual for separately considered more than any original images input [1, 2]. The methods of fusion image comprise the integration of different sources information which result high informative fused image. Image fusion is divided mainly into various levels where in this article used fusion of pixel-level, image fusion of pixel-level technique has different methods as Stationary Wavelet Transform (SWT), Discrete Wavelet Transform (DWT), Discrete Cosine Transform (DCT), Principal Component Analysis (PCA) and average weighted. SWT method is important