IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 19, Issue 7 Ser.3 (July. 2020), PP 55-60 www.iosrjournals.org DOI: 10.9790/0853-1907035560 www.iosrjournal.org 55 | Page Oral Squamous Cell Carcinoma Case Series: A Saga of Reactions Against Risk Factors Dr. Priyanka Mahawar 1 , Dr.Sreedevi Reddy 2 , Dr. Meenakshi Bhasin 3 , Dr. Ankur Kakkad 4 , Dr.Aditi Yadav 5 1 (Post Graduate Student, Department of Oral Medicine and Radiology, Hitkarini Dental College and Hospital, India) 2 (Professor and Head ,Department of Oral Medicine and Radiology, Hitkarini Dental College and Hospital, India) 3 (Reader, Department of Oral Medicine and Radiology, Hitkarini Dental College and Hospital, India) 4 (Reader, Department of Oral Medicine and Radiology, Hitkarini Dental College and Hospital, India ) 5 (Post Graduate Student, Department of Periodontics and Implantology, Hitkarini Dental College and Hospital, India) Abstract: Oral carcinoma is one of the most prevalent cancers and one of the 10 th most common causes of death across the world. It includes cancers of the lips, tongue, cheeks, floor of the mouth, hard and soft palate, sinuses, and pharynx, it can be life threatening if not diagnosed and treated early. This case report demonstrates a case series of oral squamous cell carcinoma induced because of deleterious habits and the diagnosis was confirmed by clinical, radiological and histopathological examination. It can be managed by surgery, chemotherapy, radiotherapy, or combination of all these, but regardless of its treatment modality, the 5-year survival rate is poor at about 50%. So early diagnosis of oral squamous cell carcinoma reduces morbidity and mortality associated with it and improves prognosis, therefore the dentist should have precise knowledge regarding the clinical manifestation of this deadly disease. Key Word: Neoplasia, Metastasis -------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 23-06-2020 Date of Acceptance: 11-07-2020 -------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. 1 Oral cancer is a malignant neoplasia which arises on the lip or oral cavity. Is traditionally defined as a squamous cell carcinoma (OSCC), because in the dental area, 90% of cancers are histologically originated in the squamous cells. 2 It has different levels of differentiation and a propensity for lymph node metastasis. 3 Oral squamous cell carcinoma has been defined as malignant epithelial neoplasm exhibiting squamous differentiation as characterised by the formation of keratin and /or the presence of intercellular bridges (pindborg et al 1977). 4 It is the most common malignant epithelial neoplasm affecting the oral cavity and it accounts for nearly 90% of all oral carcinomas. More than 90% of the oral cancers occur in patients over the age of 45, with a male predilection. The etiology of squamous cell carcinoma is multifactorial. The uses of tobacco and betel quid, heavy alcohol drinking, intake of diet low in fresh fruits and vegetables, viruses, trauma, and genetics are considered as possible risk factors. 5 One of the dangers of this tumor, is that in its early stages, it will go unheeded ,sometimes at the initial stages it's painless however might develop a burning sensation or pain once it's advanced. Usually, OSCC presents as an ulceration with fissuring or raised exophytic margins .It should conjointly present as a lump (as a red lesion (erythroplakia), as a white (or mixed white and red lesion, as a non-healing extraction socket or as a cervical lymphatic node, characterised by hardness or fixation. Oral squamous cell carcinoma ought to be thought-about wherever any of those options persist for a period of more than two weeks. 6