International Journal of Scientific Research and Engineering Development-– Volume 3 Issue 3, May – June 2020 Available at www.ijsred.com ISSN : 2581-7175 ©IJSRED: All Rights are Reserved Page 1181 SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY EVALUATION OF METAL(II) COMPLEXES DERIVED FROM (E) –N-BENZYLIDIENE ACETAMIDE SCHIFF BASE Usman B * , Udofia L**, Sahura A * and Fa’iza I *** * Department of Chemistry, Abubakar Tafawa Balewa University, Bauchi-Nigeria ** Department of Chemistry, Otto Von Guericke Universität Magdebug, Germany *** Department of Microbiology, Bayero University Kano-Nigeria Correspondance: usmanbello088@gmail.com ----------------------------------------************************---------------------------------- Abstract: Metal (II) complexes of Co and Ni with schiff base derived from (E)-N-benzylidieneacetamide were synthesized using microwave irradiation method and characterized on the basis of FT-IR, molar conductance, melting point, decomposition temperature and solubility test. The spectroscopic data indicated that the Schiff base ligand acted as a bidentate and coordinated to the metal via imine nitrogen and deprotonated oxygen atom. Also, the Schiff base ligand have melting point of 80-81 O C, the molar conductance values were found to be within 15.0-20.0ohm -1 cm 2 mol -1 indicating that they are non electrolytic in nature. The solubility test of the compound indicated that then compounds are soluble in water, acetone, DMF and DMSO but completely insoluble in methanol, ethanol and methylated spirit. The synthesized ligand and their metal(II) complexes were studied for their in vitro antibacterial activity against two bacterial strains; P. Aenoginosa and E. Coli. The result indicated that the complexes exhibited better activity than the ligand but less compared to the standard drug (amoxicilin). Keywords — (E)-N-benzylidiene acetamide, benzaldehyde, acetamide, Schiff base and antibacterial activity. ----------------------------------------************************---------------------------------- 1.0 INTRODUCTION The antimicrobials become resistant, and therefore they do not act on the antibiotics as expected. Thereby making treatment ineffective and this become one of the world’s most pressing public health threats, with the drug resistant bacteria causing huge number of deaths annually [1]. This is against the backdrop that the pharmaceutical and biotechnology industries are investing less and less in antibiotic discovery due to the challenges and complexities in the process, the difficulty and unpredictability of gaining regularly approval among other challenges. The accompanying loss of expertise in the sector only elevates the threat in the battle with antimicrobial resistant (AMR). Therefore, synthesis and study of coordination compounds containing biologically important ligands have been an area of interest in recent years because of their numerous applications in biology, environment and other systems [2]. The transition metals and their ions have much higher tendency to form coordination compounds as compared to the s- and p- block elements. It is because of their relatively smaller sizes, higher ionic charges and the availability of d orbital for bond formation. Coordination compounds, unlike normal compounds, retain their identity even when dissolved in water or any other suitable solvent. The properties of these compounds are totally different from those of their constituents [3]. RESEARCH ARTICLE OPEN ACCESS