IJBI 2 (2), (DECEMBER 2020) 88-94 International Journal of Biological Innovations Available online: http://ijbi.org.in | http://www.gesa.org.in/journals.php Review Article E-ISSN: 2582-1032 DOI: https://doi.org/10.46505/IJBI.2020.2202 Abstract: The COVID-19 pandemic has gripped the entire world in a medical emergency, spreading at a phenomenal rate, affecting even the most developed nations and challenging medical care infrastructure. With the precautions of social distancing and its enforcement through lockdowns, authorities have managed to buy time to flatten the curve. However, without any proven cure at hand, researchers are exploring varied approaches to treat the infected people. In this review, authors discuss the multilayered approach taken up to combat this deadly pandemic. The authors shall summarize the hospital setups, the frontline worker's struggles, the symptoms and their manifestations, preventive measures and also the current treatment approaches. Keywords: Covid-19 , Favipiravir, Plasma therapy, Social distancing, Vaccine. INTRODUCTION The ongoing Covid-19 pandemic with over 9.4 million cases worldwide and over 4,84,000 fatalities, has thrown the entire world in a health emergency. The deadly virus has challenged the healthcare systems of even the most developed countries, spreading at an alarming rate. A strategy to flatten the curve, by adopting lockdowns, in a bid to ensure social distancing proved effective in many countries. Health systems around the globe are currently preparing and working round the clock to manage the rise of the influx of critically ill patients. During this phase, care providers, administrators and policymakers work in coordination to understand and combat this deadly pandemic. The current knowledge about Covid-19 is limited but it is rapidly evolving with time. During this outbreak, the medical community has used evidence and experience from past outbreaks of SARS-CoV and MERS-CoV to predict Covid-19's behaviour, clinical presentation and treatment. In addition, coronaviruses (CoV) are known to cause signs and symptoms of multi organ system damage, many of which can go unnoticed even by trained medical professionals. Furthermore, frontline healthcare personnel lack a comprehensive review of the numerous clinical pulmonary and extra-pulmonary manifestations of deadly CoVs making self-education time consuming. COVID 19: A SYSTEMATIC APPROACH TO COMBAT THE DEADLY VIRUS Received: 30.06.2020 Published: 20.07.2020 Accepted: 15.07.2020 1 2 1* Nirupam Roy , Amitrajit Pal and Radha Chaube 1 Department of Zoology, Banaras Hindu University, Varanasi (U.P.), India 2 Grant Medical College & Sir JJ Group of Hospitals, Mumbai (Maharashtra), India *Corresponding author: chauberadha@rediffmail.com