IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 19, Issue 8 Ser.4 (August. 2020), PP 24-29 www.iosrjournals.org DOI: 10.9790/0853-1908042429 www.iosrjournal.org 24 | Page “Demographic Pattern of Amyotrophic Lateral Sclerosis in Bangladesh Among Patient Admitted in a Tertiary Level Hospital” Dr. Md. Raknuzzaman 1 , Dr. Md. Ahsan Habib 2 Tasnim Jannaty 3 ,Dr. .Abu Shams Md. Hasan Ali Masum 4 , Dr. Md. Shahidullah 5 ,Dr. SubashKanti Dey 6 1 Junior Consultant, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh 2 Associate Professor, Department of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh 3 Department of Biochemistry & Molecular Biology, Dhaka University, Dhaka, Bangladesh 4 Assistant Professor of Neurology, Anwer Khan Modern Medical College, Dhaka, Bangladesh 5 Associate Professor, Department of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka, 6 Associate Professor, Department of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Corresponding author:Dr. Md. Raknuzzaman. Abstract Background: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease (MND) that affects both upper and lower motor neurons. The prevalence of people living with ALS, varies among geographic regions worldwide. For the betterment of the patients with amyotrophic lateral sclerosis it is very important to have the proper knowledge on the demographic pattern of amyotrophic lateral sclerosis. Aim of the Study: The aim of this study was to evaluate the demographic pattern of amyotrophic lateral sclerosis in Bangladesh. Methodology & Materials: This hospital-based prospective cohort study was conducted in the Department of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh during the period from January 2010 to December 2011. Among 56 MND patients from first screening in total 34 patients with ALS, completed the full tenure of the study were finalized as the study population. The demographic profile, clinical characteristics and risk factors were systematically recorded. Results: In this study among total 34 participants, the highest 41% (n=14) participants were from 41-50 years’ age group. Male were 59% (n=20) and female were 41% (n=14). In total 47%, 41% and 12% participants were from lower, middle and upper class families respectively. We observed 58.82% participants had classical ALS. On the other hand, 17.65% participants had juvenile form of ALS and 23.53% participants had Monomelicamyotrophy. Cognitive impairment was found negative among all the participants. Both UMN and MLN were found among 100% patients. Conclusion: In this study we found gender and age of the participants was potential aspect regarding amyotrophic lateral sclerosis (ALS) disease. All the findings of this study may be helpful for farther similar studies and in the treatment procedure of ALS. Key words:ALS, sclerosis, amyotrophic. --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 24-07-2020 Date of Acceptance: 08-08-2020 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Amyotrophic lateral sclerosis (ALS) is a type of motor neuron disease (MND). Motor neuron disease (MND) is used to designate a progressive degenerative disorder of motor neurons in spinal cord, brainstem and motor cortex manifest clinically by muscular weakness, atrophy and corticospinal tract signs in varying combinations. It is a disease of middle life, for the most part and progress to death in a matter of 2 to 6 years or longer in exceptional cases. MND’s are progressive diseases of adults resulting fro m variable degeneration of the upper motor and lower motor neurons. The recognized types, which display considerable clinical similarity, are sporadic, 1 familial and western pacific forms. 2 The diagnostic criteria of the disease have been established by the World Federation of Neurology Subcommittee on motor neuron diseases. Its clinical variants result either from predominant degeneration of the LMNs of limb muscles (PMA) or bulbar muscles (progressive bulbar palsy, PBP) or the UMNs (primary lateral sclerosis and progressive pseudobulbar palsy). However, these forms may be distinguishable only early in the disease, as most patients eventually develop clinical and pathological features of UMN and LMN involvement. This is a common disease, with an annual incidence rate of 0.4% to 1.76% per 100,000 populations. Men are affected somewhat more frequently than women. Male to female ration is approximately 1.6:1. Most patients are more than 50 years old at the onset of symptoms and the incidence increase with each decade of life. The disease occurs in a random pattern throughout the world except for a